Tiffany N. Seagroves

Associate Professor

  • 2244 Citations
  • 19 h-Index
19962019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2019

  • 2244 Citations
  • 19 h-Index
  • 34 Article
  • 3 Chapter
  • 3 Review article
  • 2 Comment/debate
2019
1 Citation (Scopus)

Activation of estrogen receptor alpha by decitabine inhibits osteosarcoma growth and metastasis

Osuna, M. A. L., Garcia-Lopez, J., Ayachi, I. E., Fatima, I., Khalid, A. B., Kumpati, J., Slayden, A. V., Seagroves, T., Miranda-Carboni, G. & Miranda, S., Jan 1 2019, In : Cancer Research. 79, 6, p. 1054-1068 15 p.

Research output: Contribution to journalArticle

decitabine
Estrogen Receptor alpha
Osteosarcoma
Osteoblasts
Neoplasm Metastasis
1 Citation (Scopus)

Colchicine binding site agent DJ95 overcomes drug resistance and exhibits antitumor efficacy

Arnst, K. E., Wang, Y., Lei, Z. N., Hwang, D. J., Kumar, G., Ma, D., Parke, D. N., Chen, Q., Yang, J., White, S. W., Seagroves, T., Chen, Z. S., Miller, D. & Li, W., Jan 1 2019, In : Molecular pharmacology. 96, 1, p. 73-89 17 p.

Research output: Contribution to journalArticle

Colchicine
Drug Resistance
Binding Sites
Cell Line
ATP-Binding Cassette Transporters
2 Citations (Scopus)

The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer

Ayachi, I. E., Fatima, I., Wend, P., Alva-Ornelas, J. A., Runke, S., Kuenzinger, W. L., Silva, J., Silva, W., Gray, J. K., Lehr, S., Barch, H. C., Krutilina, R. I., White, A. C., Cardiff, R., Yee, L. D., Yang, L., O'Regan, R. M., Lowry, W. E., Seagroves, T., Seewaldt, V. & 2 others, Miranda, S. & Miranda-Carboni, G., Mar 1 2019, In : Cancer Research. 79, 5, p. 982-993 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplasm Metastasis
Survival
Heterografts
Doxorubicin
2018

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

Sethuraman, A., Brown, M., Krutilina, R., Wu, Z., Seagroves, T., Pfeffer, L. & Fan, M., Oct 1 2018, In : Breast Cancer Research. 20, 1, 117.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Heparin
Breast Neoplasms
Neoplasm Metastasis
Phenotype

Chromatin immunoprecipitation of HIF-α in breast tumor cells using wild type and loss of function models

Brooks, D. L. & Seagroves, T., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 67-79 13 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chromatin Immunoprecipitation
Breast Neoplasms
Hypoxia-Inducible Factor 1
Response Elements
Epithelial Cells

Correction: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer (PLoS One (2017) 12:12 (e0189864) DOI: 10.1371/journal.pone.0189864)

Fatima, I., El-Ayachi, I., Taotao, L., Angeles Lillo, M., Krutilina, R. I., Seagroves, T., Radaszkiewicz, T. W., Hutnan, M., Bryja, V., Miranda, S., Rivas, F. & Miranda-Carboni, G., May 1 2018, In : PloS one. 13, 5, e0197796.

Research output: Contribution to journalComment/debate

Triple Negative Breast Neoplasms
Catenins
breast neoplasms
Names
jatrophone

Fluorescence-activated cell sorting of murine mammary cancer stem-like cell subpopulations with HIF activity

Brooks, D. L. & Seagroves, T., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 247-263 17 p. (Methods in Molecular Biology; vol. 1742).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplastic Stem Cells
Flow Cytometry
Breast Neoplasms
Neoplasms
Mouse mammary tumor virus

Taxol induces brk-dependent prosurvival phenotypes in TNBC cells through an AhR/GR/HIF-driven signaling axis

Anderson, T. M. R., Ma, S., Kerkvliet, C. P., Peng, Y., Helle, T. M., Krutilina, R. I., Raj, G. V., Cidlowski, J. A., Ostrander, J. H., Schwertfeger, K. L., Seagroves, T. & Lange, C. A., Nov 1 2018, In : Molecular Cancer Research. 16, 11, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Glucocorticoid Receptors
Paclitaxel
Breast Neoplasms
Phenotype
2017
7 Citations (Scopus)

Bisphenol A Induces Sox2 in ER+ Breast Cancer Stem-Like Cells

Lillo Osuna, M. A., Nichols, C., Seagroves, T., Miranda-Carboni, G. & Miranda, S., Apr 1 2017, In : Hormones and Cancer. 8, 2, p. 90-99 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Breast Neoplasms
MCF-7 Cells
Cell Proliferation
Food and Beverages
8 Citations (Scopus)

Methylparaben stimulates tumor initiating cells in ER+ breast cancer models

Lillo Osuna, M. A., Nichols, C., Perry, C., Runke, S., Krutilina, R., Seagroves, T., Miranda-Carboni, G. & Miranda, S., Apr 1 2017, In : Journal of Applied Toxicology. 37, 4, p. 417-425 9 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Tumors
Breast Neoplasms
Endocrine Disruptors
Estrogens
8 Citations (Scopus)

The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

Fatima, I., El-Ayachi, I., Taotao, L., Lillo Osuna, M. A., Krutilina, R., Seagroves, T., Radaszkiewicz, T. W., Hutnan, M., Bryja, V., Miranda, S., Rivas, F. & Miranda-Carboni, G., Dec 1 2017, In : PloS one. 12, 12, e0189864.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Catenins
breast neoplasms
Cells
cell lines
2016
12 Citations (Scopus)

Breast tumor kinase (Brk/PTK6) is induced by HIF, glucocorticoid receptor, and PELP1-mediated stress signaling in triple-negative breast cancer

Regan Anderson, T. M., Ma, S. H., Raj, G. V., Cidlowski, J. A., Helle, T. M., Knutson, T. P., Krutilina, R. I., Seagroves, T. & Lange, C. A., Mar 15 2016, In : Cancer Research. 76, 6, p. 1653-1663 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Glucocorticoid Receptors
Phosphotransferases
Breast Neoplasms
Dexamethasone
38 Citations (Scopus)

ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

Brooks, D. L. P., Schwab, L. P., Krutilina, R., Parke, D. N., Sethuraman, A., Hoogewijs, D., Schörg, A., Gotwald, L., Fan, M., Wenger, R. H. & Seagroves, T., Mar 22 2016, In : Molecular Cancer. 15, 1, 26.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Breast Neoplasms
Integrins
Phenotype
Integrin alpha6
6 Citations (Scopus)

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway

Sethuraman, A., Brown, M., Seagroves, T., Wu, Z., Pfeffer, L. & Fan, M., Aug 5 2016, In : Breast Cancer Research. 18, 1, 81.

Research output: Contribution to journalArticle

Anoikis
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Lung
2015
9 Citations (Scopus)

Assessment of the tumorigenic potential of spontaneously immortalized and hTERT immortalized cultured dental pulp stem cells

Wilson, R., Urraca, N., Skobowiat, C., Hope, K. A., Miravalle, L., Chamberlin, R., Donaldson, M., Seagroves, T. & Reiter, L., Jul 27 2015, In : Stem Cells Translational Medicine. 4, 8, p. 905-912 8 p.

Research output: Contribution to journalArticle

Dental Pulp
Stem Cells
Cell Line
Genomic Instability
Neurons
39 Citations (Scopus)

MTOR/MYCAxis regulates O-GlcNAc transferase expression and O-GlcN acylation in breast cancer

Sodi, V. L., Khaku, S., Krutilina, R., Schwab, L. P., Vocadlo, D. J., Seagroves, T. & Reginato, M. J., May 1 2015, In : Molecular Cancer Research. 13, 5, p. 923-933 11 p.

Research output: Contribution to journalArticle

Acylation
Breast Neoplasms
Neoplasms
Glutamine
Phosphatidylinositol 3-Kinases
2014
4 Citations (Scopus)

Benzimidazole analogs as potent hypoxia inducible factor inhibitors: Synthesis, biological evaluation, and profiling drug-like properties

Chen, J., Wang, J., Schwab, L. P., Park, K. T., Seagroves, T., Jennings, L. K., Miller, D. & Li, W., Aug 1 2014, In : Anticancer research. 34, 8, p. 3891-3904 14 p.

Research output: Contribution to journalArticle

Drug Evaluation
Platelet Aggregation
Protein Binding
Solubility
Western Blotting
5 Citations (Scopus)

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland

Paatero, I., Seagroves, T., Vaparanta, K., Han, W., Jones, F. E., Johnson, R. S. & Elenius, K., Aug 8 2014, In : Journal of Biological Chemistry. 289, 32, p. 22459-22469 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Human Mammary Glands
Proteins
Breast
Epithelial Cells
39 Citations (Scopus)

MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers

Krutilina, R., Sun, W. L., Sethuraman, A., Brown, M., Seagroves, T., Pfeffer, L., Ignatova, T. & Fan, M., Jul 28 2014, In : Breast Cancer Research. 16, 4, R78.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
MicroRNAs
Breast Neoplasms
Neoplasm Metastasis
Lung
121 Citations (Scopus)

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

Ferrer, C. M., Lynch, T. P., Sodi, V. L., Falcone, J. N., Schwab, L. P., Peacock, D. L., Vocadlo, D. J., Seagroves, T. & Reginato, M. J., Jun 5 2014, In : Molecular Cell. 54, 5, p. 820-831 12 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Survival
Neoplasms
Transcription Factor CHOP
Hexosamines
69 Citations (Scopus)

The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways

Slominski, A., Kim, T. K., Brozyna, A. A., Janjetovic, Z., Brooks, D. L. P., Schwab, L. P., Skobowiat, C., Jóźwicki, W. & Seagroves, T., Dec 15 2014, In : Archives of Biochemistry and Biophysics. 563, p. 79-93 15 p.

Research output: Contribution to journalArticle

Metabolism
Melanoma
Genes
Cells
Up-Regulation
2013
24 Citations (Scopus)

Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer

Hallett, M. A., Teng, B., Hasegawa, H., Schwab, L. P., Seagroves, T. & Pourmotabbed, T., Feb 13 2013, In : Breast Cancer Research. 15, 1, R12.

Research output: Contribution to journalArticle

Catalytic DNA
Matrix Metalloproteinase 9
Breast Neoplasms
Growth
Neoplasms
25 Citations (Scopus)

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia- associated breast cancer progression

Anderson, T. M. R., Peacock, D. L., Daniel, A. R., Hubbard, G. K., Lofgren, K. A., Girard, B. J., Schorg, A., Hoogewijs, D., Wenger, R. H., Seagroves, T. & Lange, C. A., Sep 15 2013, In : Cancer Research. 73, 18, p. 5810-5820 11 p.

Research output: Contribution to journalArticle

Phosphotransferases
Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
11 Citations (Scopus)

Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer

Wang, C., Schwab, L. P., Fan, M., Seagroves, T. & Buolamwini, J. K., May 1 2013, In : Cancer Prevention Research. 6, 5, p. 437-447 11 p.

Research output: Contribution to journalArticle

Dipyridamole
Chemoprevention
Transgenic Mice
Breast Neoplasms
MicroRNAs
18 Citations (Scopus)

Putative role of hif transcriptional activity in melanocytes and melanoma biology

Zbytek, B., Peacock, D. L., Seagroves, T. & Slominski, A., Apr 1 2013, In : Dermato-Endocrinology. 5, 2, p. 239-251 13 p.

Research output: Contribution to journalReview article

Hypoxia-Inducible Factor 1
Melanocytes
Melanoma
Genes
Basic Helix-Loop-Helix Transcription Factors
44 Citations (Scopus)

The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance

Whelan, K. A., Schwab, L. P., Karakashev, S. V., Franchetti, L., Johannes, G. J., Seagroves, T. & Reginato, M. J., May 31 2013, In : Journal of Biological Chemistry. 288, 22, p. 15865-15877 13 p.

Research output: Contribution to journalArticle

Anoikis
Hypoxia-Inducible Factor 1
Oncogenes
Tumors
Breast Neoplasms
2012
113 Citations (Scopus)

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

Schwab, L. P., Peacock, D. L., Majumdar, D., Ingels, J. F., Jensen, L. C., Smith, K. D., Cushing, R. C. & Seagroves, T., Jan 7 2012, In : Breast Cancer Research. 14, 1, R6.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neoplastic Stem Cells
Breast Neoplasms
Growth
Neoplasms
2010
9 Citations (Scopus)

Dose-dependent modulation of HIF-1α/sima controls the rate of cell migration and invasion in Drosophila ovary border cells

Doronkin, S., Djagaeva, I., Nagle, M. E., Reiter, L. & Seagroves, T., Feb 1 2010, In : Oncogene. 29, 8, p. 1123-1134 12 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Drosophila
Cell Movement
Ovary
Cadherins
9 Citations (Scopus)

VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis

Seagroves, T., Peacock, D. L., Liao, D., Schwab, L. P., Krueger, R., Handorf, C. R., Haase, V. H. & Johnson, R. S., Jan 1 2010, In : American Journal of Pathology. 176, 5, p. 2269-2282 14 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Carcinogenesis
Breast
Epithelium
Lactation
2009
3 Citations (Scopus)

The complexity of the HIF-1-dependent hypoxic response in breast cancer presents multiple avenues for therapeutic intervention

Seagroves, T., Dec 1 2009, Pharmaceutical Perspectives of Cancer Therapeutics. Springer US, p. 521-558 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypoxia-Inducible Factor 1
Tumors
Breast Neoplasms
Cells
Neoplasms
2008
23 Citations (Scopus)

The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis

Golipour, A., Myers, D., Seagroves, T., Murphy, D., Evan, G. I., Donoghue, D. J., Moorehead, R. A. & Porter, L. A., May 15 2008, In : Cancer Research. 68, 10, p. 3591-3600 10 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Cell Cycle
Carcinogenesis
Breast
myc Genes
2007
241 Citations (Scopus)

Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression

Liao, D., Corle, C., Seagroves, T. & Johnson, R. S., Jan 15 2007, In : Cancer Research. 67, 2, p. 563-572 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neoplasm Metastasis
Neoplasms
Breast
Epithelium
2006
69 Citations (Scopus)

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase

Reiter, L., Seagroves, T., Bowers, M. & Bier, E., Sep 15 2006, In : Human molecular genetics. 15, 18, p. 2825-2835 11 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Drosophila
Angelman Syndrome
Head
Proteins
2003
59 Citations (Scopus)

HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

Seagroves, T., Hadsell, D., McManaman, J., Palmer, C., Liao, D., McNulty, W., Welm, B., Wagner, K. U., Neville, M. & Johnson, R. S., Apr 1 2003, In : Development. 130, 8, p. 1713-1724 12 p.

Research output: Contribution to journalReview article

Human Mammary Glands
Blood Vessels
Breast
Lactation
Epithelium
2002
86 Citations (Scopus)

Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development

Grimm, S. L., Seagroves, T., Kabotyanski, E. B., Hovey, R. C., Vonderhaar, B. K., Lydon, J. P., Miyoshi, K., Hennighausen, L., Ormandy, C. J., Lee, A. V., Stull, M. A., Wood, T. L. & Rosen, J. M., Dec 1 2002, In : Molecular Endocrinology. 16, 12, p. 2675-2691 17 p.

Research output: Contribution to journalArticle

Prolactin Receptors
Steroid Receptors
Human Mammary Glands
Progesterone Receptors
CCAAT-Enhancer-Binding Proteins

Erratum: Two HIFs may be better than one (Cancer Cell 2002 (212))

Seagroves, T. & Johnson, R. S., Jan 1 2002, In : Cancer Cell. 1, 4, 1 p.

Research output: Contribution to journalComment/debate

Neoplasms
34 Citations (Scopus)

Two HIFs may be better than one

Seagroves, T. & Johnson, R. S., Jan 1 2002, In : Cancer Cell. 1, 3, p. 211-213 3 p.

Research output: Contribution to journalReview article

Carcinogens
Carcinogenesis
Kidney
2001
358 Citations (Scopus)

IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

Cao, Y., Bonizzi, G., Seagroves, T., Greten, F. R., Johnson, R., Schmidt, E. V. & Karin, M., Dec 14 2001, In : Cell. 107, 6, p. 763-775 13 p.

Research output: Contribution to journalArticle

Cyclin D1
Human Mammary Glands
Breast
Chemical activation
Epithelial Cells
404 Citations (Scopus)

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells

Seagroves, T., Ryan, H. E., Lu, H., Wouters, B. G., Knapp, M., Thibault, P., Laderoute, K. & Johnson, R. S., May 9 2001, In : Molecular and cellular biology. 21, 10, p. 3436-3444 9 p.

Research output: Contribution to journalArticle

Transcription Factors
Adenosine Triphosphate
Oxidative Phosphorylation
Fermentation
Vascular System Injuries
2000
138 Citations (Scopus)

C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development

Seagroves, T., Lydon, J. P., Hovey, R. C., Vonderhaar, B. K. & Rosen, J. M., Dec 1 2000, In : Molecular Endocrinology. 14, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Progesterone Receptors
Human Mammary Glands
Bromodeoxyuridine
Breast
1998
207 Citations (Scopus)

C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland

Seagroves, T., Krnacik, S., Raught, B., Gay, J., Burgess-Beusse, B., Darlington, G. J. & Rosen, J. M., Jun 15 1998, In : Genes and Development. 12, 12, p. 1917-1928 12 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Human Mammary Glands
Morphogenesis
Breast
Caseins
1996

C/EBP activity is regulated by ecm and may mediate β-casein gene expression

Seagroves, T. & Rosen, J. M., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Caseins
Gene expression
Gene Expression
Plastics