α-smooth muscle actin-positive fibroblasts correlate with poor survival in hepatocellular carcinoma

Jignesh G. Parikh, Anand Kulkarni, Cameila Johns

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Center (Memphis, TN, USA) between January 2000 and December 2009, and 10 age- and gender-matched controls with normal liver biopsy samples were included in the study. The immunohistochemical staining for α-SMA was performed and classified qualitatively and quantitatively within tumor stroma and perisinusoidal spaces. HCC patients with high qualitative and quantitative expression of α-SMA revealed a statistically significant negative correlation with 3-year [odds ratio (OR), 0.021 and 0.111; P=0.001 and 0.0302, respectively] and 1.5-year (OR, 0.040 and 0.051; P=0.0330 and 0.0492, respectively) survival rates in comparison with low expression. The results of the present study demonstrated a predictive role of high qualitative and quantitative expression in activated fibroblasts for poor survival in patients with HCC.

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalOncology Letters
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2014

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Smooth Muscle
Actins
Hepatocellular Carcinoma
Fibroblasts
Survival
Odds Ratio
Biopsy
Liver
Veterans
Case-Control Studies
Survival Rate
Staining and Labeling
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

α-smooth muscle actin-positive fibroblasts correlate with poor survival in hepatocellular carcinoma. / Parikh, Jignesh G.; Kulkarni, Anand; Johns, Cameila.

In: Oncology Letters, Vol. 7, No. 2, 01.02.2014, p. 573-575.

Research output: Contribution to journalArticle

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