α8-Integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning

C. S. Chan, H. Chen, A. Bradley, Ioannis Dragatsis, C. Rosenmund, R. L. Davis

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Integrins are heterodimeric transmembrane cell adhesion receptors that are essential for a wide range of biological functions via cell-matrix and cell-cell interactions. Recent studies have provided evidence that some of the subunits in the integrin family are involved in synaptic and behavioral plasticity. To further understand the role of integrins in the mammalian central nervous system, we generated a postnatal forebrain and excitatory neuron-specific knockout of α8-integrin in the mouse. Behavioral studies showed that the mutant mice are normal in multiple hippocampal-dependent learning tasks, including a T-maze, non-match-to-place working memory task for which other integrin subunits like α3-and β1-integrin are required. In contrast, mice mutant for α8-integrin exhibited a specific impairment of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, whereas basal synaptic transmission, paired-pulse facilitation and long-term depression (LTD) remained unaffected. Because LTP is also impaired in the absence of α3-integrin, our results indicate that multiple integrin molecules are required for the normal expression of LTP, and different integrins display distinct roles in behavioral and neurophysiological processes like synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)402-410
Number of pages9
JournalGenes, Brain and Behavior
Volume9
Issue number4
DOIs
StatePublished - Jun 1 2010

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Long-Term Potentiation
Integrins
Learning
Neuronal Plasticity
Prosencephalon
Short-Term Memory
Cell Adhesion
Cell Communication
Synaptic Transmission
Synapses
Hippocampus
Central Nervous System
Depression
Neurons

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

α8-Integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning. / Chan, C. S.; Chen, H.; Bradley, A.; Dragatsis, Ioannis; Rosenmund, C.; Davis, R. L.

In: Genes, Brain and Behavior, Vol. 9, No. 4, 01.06.2010, p. 402-410.

Research output: Contribution to journalArticle

Chan, C. S. ; Chen, H. ; Bradley, A. ; Dragatsis, Ioannis ; Rosenmund, C. ; Davis, R. L. / α8-Integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning. In: Genes, Brain and Behavior. 2010 ; Vol. 9, No. 4. pp. 402-410.
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