Δ9-Tetrahydrocannabinol-methamphetamine interaction in the rabbit

P. F. Consroe, Byron Jones, Faren Akins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The combined effects of Δ9-tetrahydrocannabinol (Δ9-THC) and methamphetamine on the electroencephalogram and behaviour, were measured in adult unrestrained rabbits. The increase in mean cortical electrogenesis (voltage output) of the electroencephalogram, induced by Δ9-THC, was clearly reversed by methamphetamine. Hippocampal theta rhythm disrupted by Δ9-THC was restored by methamphetamine. Methamphetamine also antagonized Δ9-THC-induced alteration of postural and activity behaviours. Moreover, striking "pathological" behaviour resulted from the Δ9-THC-methamphetamine combination. These data indicate that both antagonism and potentiation occurred with the Δ9-THC-methamphetamine treatment sequence.

Original languageEnglish (US)
Pages (from-to)377-383
Number of pages7
JournalNeuropharmacology
Volume14
Issue number5-6
DOIs
StatePublished - Jan 1 1975

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Dronabinol
Methamphetamine
Rabbits
Electroencephalography
Theta Rhythm

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Δ9-Tetrahydrocannabinol-methamphetamine interaction in the rabbit. / Consroe, P. F.; Jones, Byron; Akins, Faren.

In: Neuropharmacology, Vol. 14, No. 5-6, 01.01.1975, p. 377-383.

Research output: Contribution to journalArticle

Consroe, P. F. ; Jones, Byron ; Akins, Faren. / Δ9-Tetrahydrocannabinol-methamphetamine interaction in the rabbit. In: Neuropharmacology. 1975 ; Vol. 14, No. 5-6. pp. 377-383.
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