2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography sensitivity to serum glucose

A survey and diagnostic applications

Joseph A. Thie, Gary T. Smith, Karl Hubner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The positron emission tomography (PET) clinical utility of the sensitivity (γ) of uptake (Q) to a change in plasma glucose concentration (C) is investigated. Methods: γ is obtained from data as [ln(Q2/ Q1)]/[ln(C2/C1)], using previously published intrapatient studies varying C within a single patient and some interpatient ones. It can be theoretically related to the half-saturation constant in the Michaelis-Menten quantification of competitive uptake. One of its uses is making uptake corrections for desired vs. actual C using Q2 = Q1(C2 C1)γ. Results: Intrapatient studies proved to be preferable to interpatient ones, and a 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET survey with analyses for γ yielded the following result: usually the γ values of tumors and brain tissues were near -1, whereas those of other noncerebral tissues were near 0. Regarding correcting uptakes for C, instead of a universally assumed and applied γ = -1, corrections should be for a single tissue using its known γ. An advantageous use of γ is predicting how C affects image contrast, including where glucose loading is sometimes preferable to fasting. Conclusions: A potentially useful quantifier of uptake sensitivity to plasma glucose has been defined and values obtained. Correcting uptakes to some standard C requires special care. γ can help PET clinicians select fasting or loading to achieve glucose levels for optimum contrast.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalMolecular Imaging and Biology
Volume7
Issue number5
DOIs
StatePublished - Sep 1 2005

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Positron-Emission Tomography
Glucose
Serum
Fasting
Brain Neoplasms
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Radiology Nuclear Medicine and imaging

Cite this

2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography sensitivity to serum glucose : A survey and diagnostic applications. / Thie, Joseph A.; Smith, Gary T.; Hubner, Karl.

In: Molecular Imaging and Biology, Vol. 7, No. 5, 01.09.2005, p. 361-368.

Research output: Contribution to journalArticle

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