25-hydroxyvitamin D status and change in physical performance and strength in older adults

Denise K. Houston, Janet A. Tooze, Rebecca H. Neiberg, Dorothy B. Hausman, Mary Ann Johnson, Jane A. Cauley, Doug C. Bauer, Peggy M. Cawthon, M. Kyla Shea, Gary G. Schwartz, Jeff D. Williamson, Frances Tylavsky, Marjolein Visser, Eleanor M. Simonsick, Tamara B. Harris, Stephen B. Kritchevsky

Research output: Contribution to journalArticle

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Abstract

Low 25-hydroxyvitamin D (25(OH)D) concentrations are common among older adults and are associated with poorer physical performance and strength, but results from longitudinal studies have been inconsistent. The 25(OH)D threshold for physical performance and strength was determined, and both cross-sectional and longitudinal associations between 25(OH)D and physical performance and strength were examined, in men and women aged 71-80 years from the Health, Aging, and Body Composition Study (n 2,641). Baseline serum 25(OH)D was measured in 1998-1999, and physical performance and strength were measured at baseline and at 2-and 4-year follow-up. Piecewise regression models were used to determine 25(OH)D thresholds. Linear regression and mixed models were used to examine cross-sectional and longitudinal associations. The 25(OH)D thresholds were 70-80 nmol/L for physical performance and 55-70 nmol/L for strength. Participants with 25(OH)D <50 nmol/L had poorer physical performance at baseline and at 2-and 4-year follow-up than participants with 25(OH)D <75 nmol/L (P < 0.01). Although physical performance and strength declined over 4 years of follow-up (P < 0.0001), in general, the rate of decline was not associated with baseline 25(OH)D. Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength.

Original languageEnglish (US)
Pages (from-to)1025-1034
Number of pages10
JournalAmerican Journal of Epidemiology
Volume176
Issue number11
DOIs
StatePublished - Dec 1 2012

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Body Composition
Longitudinal Studies
Linear Models
Health
Serum
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Houston, D. K., Tooze, J. A., Neiberg, R. H., Hausman, D. B., Johnson, M. A., Cauley, J. A., ... Kritchevsky, S. B. (2012). 25-hydroxyvitamin D status and change in physical performance and strength in older adults. American Journal of Epidemiology, 176(11), 1025-1034. https://doi.org/10.1093/aje/kws147

25-hydroxyvitamin D status and change in physical performance and strength in older adults. / Houston, Denise K.; Tooze, Janet A.; Neiberg, Rebecca H.; Hausman, Dorothy B.; Johnson, Mary Ann; Cauley, Jane A.; Bauer, Doug C.; Cawthon, Peggy M.; Shea, M. Kyla; Schwartz, Gary G.; Williamson, Jeff D.; Tylavsky, Frances; Visser, Marjolein; Simonsick, Eleanor M.; Harris, Tamara B.; Kritchevsky, Stephen B.

In: American Journal of Epidemiology, Vol. 176, No. 11, 01.12.2012, p. 1025-1034.

Research output: Contribution to journalArticle

Houston, DK, Tooze, JA, Neiberg, RH, Hausman, DB, Johnson, MA, Cauley, JA, Bauer, DC, Cawthon, PM, Shea, MK, Schwartz, GG, Williamson, JD, Tylavsky, F, Visser, M, Simonsick, EM, Harris, TB & Kritchevsky, SB 2012, '25-hydroxyvitamin D status and change in physical performance and strength in older adults', American Journal of Epidemiology, vol. 176, no. 11, pp. 1025-1034. https://doi.org/10.1093/aje/kws147
Houston DK, Tooze JA, Neiberg RH, Hausman DB, Johnson MA, Cauley JA et al. 25-hydroxyvitamin D status and change in physical performance and strength in older adults. American Journal of Epidemiology. 2012 Dec 1;176(11):1025-1034. https://doi.org/10.1093/aje/kws147
Houston, Denise K. ; Tooze, Janet A. ; Neiberg, Rebecca H. ; Hausman, Dorothy B. ; Johnson, Mary Ann ; Cauley, Jane A. ; Bauer, Doug C. ; Cawthon, Peggy M. ; Shea, M. Kyla ; Schwartz, Gary G. ; Williamson, Jeff D. ; Tylavsky, Frances ; Visser, Marjolein ; Simonsick, Eleanor M. ; Harris, Tamara B. ; Kritchevsky, Stephen B. / 25-hydroxyvitamin D status and change in physical performance and strength in older adults. In: American Journal of Epidemiology. 2012 ; Vol. 176, No. 11. pp. 1025-1034.
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