[6] C1 Inhibitor

Alvin E. Davis, Kulwant S. Aulak, Kamyar Zahedi, John Bissler, Richard A. Harrison

Research output: Contribution to journalArticle

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Abstract

This chapter discusses C1 inhibitor (C1 INH). C1 INH is a member of the serine proteinase inhibitor (serpin) superfamily. C1 INH is the only physiologically important plasma inhibitor of activated Clr and Cls, and it provides a major portion of the plasma inhibitory capacity toward kallikrein and factor XIIa, but probably is not normally an important inactivator of XIa or plasmin. The primary role of C1 INH is as a regulator of the complement and contact (kinin-forming) systems, and perhaps (directly or indirectly) of the fibrinolytic system. In vitro, C1 INH subsequently is shown to inactivate several other plasma proteases, including kallikrein, plasmin, plasminogen activator, and factors XIa and XIIa (Hageman factor). C1 INH is the only physiologically important plasma inhibitor of activated Clr and Cls, and it provides a major portion of the plasma inhibitory capacity toward kallikrein and factor XIIa, but probably is not normally an important inactivator of XIa or plasmin. The primary role of C1 INH is as a regulator of the complement and contact (kinin-forming) systems, and perhaps (directly or indirectly) of the fibrinolytic system.

Original languageEnglish (US)
Pages (from-to)97-120
Number of pages24
JournalMethods in enzymology
Volume223
Issue numberC
DOIs
StatePublished - Jan 1 1993

Fingerprint

Factor XIIa
Kallikreins
Fibrinolysin
Plasmas
Kinins
Factor XIa
Factor XII
Serine Proteinase Inhibitors
Plasminogen Activators
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Davis, A. E., Aulak, K. S., Zahedi, K., Bissler, J., & Harrison, R. A. (1993). [6] C1 Inhibitor. Methods in enzymology, 223(C), 97-120. https://doi.org/10.1016/0076-6879(93)23040-T

[6] C1 Inhibitor. / Davis, Alvin E.; Aulak, Kulwant S.; Zahedi, Kamyar; Bissler, John; Harrison, Richard A.

In: Methods in enzymology, Vol. 223, No. C, 01.01.1993, p. 97-120.

Research output: Contribution to journalArticle

Davis, AE, Aulak, KS, Zahedi, K, Bissler, J & Harrison, RA 1993, '[6] C1 Inhibitor', Methods in enzymology, vol. 223, no. C, pp. 97-120. https://doi.org/10.1016/0076-6879(93)23040-T
Davis AE, Aulak KS, Zahedi K, Bissler J, Harrison RA. [6] C1 Inhibitor. Methods in enzymology. 1993 Jan 1;223(C):97-120. https://doi.org/10.1016/0076-6879(93)23040-T
Davis, Alvin E. ; Aulak, Kulwant S. ; Zahedi, Kamyar ; Bissler, John ; Harrison, Richard A. / [6] C1 Inhibitor. In: Methods in enzymology. 1993 ; Vol. 223, No. C. pp. 97-120.
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