A Bayesian approach for sample size determination in method comparison studies

Kunshan Yin, Pankaj K. Choudhary, Diana Varghese, Steven Goodman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Studies involving two methods for measuring a continuous response are regularly conducted in health sciences to evaluate agreement of a method with itself and agreement between methods. Notwithstanding their wide usage, the design of such studies, in particular, the sample size determination, has not been addressed in the literature when the goal is the simultaneous evaluation of intra- and inter-method agreement. We fill this need by developing a simulation-based Bayesian methodology for determining sample sizes in a hierarchical model framework. Unlike a frequentist approach, it takes into account uncertainty in parameter estimates. This methodology can be used with any scalar measure of agreement available in the literature. We demonstrate this for four currently used measures. The proposed method is applied to an ongoing proteomics project, where we use pilot data to determine the number of individuals and the number of replications needed to evaluate the agreement between two methods for measuring protein ratios. We also apply our method to determine the sample size for an experiment involving measurement of blood pressure.

Original languageEnglish (US)
Pages (from-to)2273-2289
Number of pages17
JournalStatistics in Medicine
Volume27
Issue number13
DOIs
StatePublished - Jun 15 2008
Externally publishedYes

Fingerprint

Method Comparison
Sample Size Determination
Bayes Theorem
Bayesian Approach
Sample Size
Methodology
Evaluate
Proteomics
Blood Pressure
Hierarchical Model
Replication
Uncertainty
Health
Scalar
Protein

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability

Cite this

A Bayesian approach for sample size determination in method comparison studies. / Yin, Kunshan; Choudhary, Pankaj K.; Varghese, Diana; Goodman, Steven.

In: Statistics in Medicine, Vol. 27, No. 13, 15.06.2008, p. 2273-2289.

Research output: Contribution to journalArticle

Yin, Kunshan ; Choudhary, Pankaj K. ; Varghese, Diana ; Goodman, Steven. / A Bayesian approach for sample size determination in method comparison studies. In: Statistics in Medicine. 2008 ; Vol. 27, No. 13. pp. 2273-2289.
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