A case-crossover study of wintertime ambient air pollution and infant bronchiolitis

Catherine Karr, Thomas Lumley, Kristen Shepherd, Robert Davis, Timothy Larson, Beate Ritz, Joel Kaufman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We examined the association of infant bronchiolitis with acute exposure to ambient air pollutants. Design: We employed a time-stratified case-c rossover method and based the exposure windows on a priori, biologically based hypotheses. Partic ipants: We evaluated effects in 19,901 infants in the South Coast Air Basin of California in 1995-2000 with a hospital discharge record for bronchiolitis in the first year of life (International Classification of Diseases, 9th Revision, CM466.1). Evaluations/Measurements: Study subjects' ZIP code was linked to ambient air pollution monitors to derive exposures. We estimated the risk of bronchiolitis hospitalization associated with increases in wintertime ambient air pollutants using conditional logistic regression. Results: We observed no increased risk after acute exposure to particul ate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5), carbon monoxide, or nitrogen dioxide PM2.5 exposure models suggested a 26-41% increased risk in the most premature infants born at gestational ages between 25 and 29 weeks; however, these findings were based on very small numbers. Conclusions: We found little support for a link between acute increases in ambient air pollution and infant bronchiolitis except modestly increased risk for PM2.5 exposure among infants born very prematurely. In these infants, the periods of viral acquisition and incubation concurred with the time of increased risk. Relevance to Professional Practice: We present novel data for the infant period and the key respiratory disease of infancy, bronchiolitis. Incompletely explained trends in rising bronchiolitis hospitalization rates and increasing number of infants born prematurely underscore the importance of evaluating the impact of ambient air pollution in this age group in other populations and studies.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalEnvironmental Health Perspectives
Volume114
Issue number2
DOIs
StatePublished - Feb 1 2006

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Bronchiolitis
Air Pollution
Air pollution
Cross-Over Studies
ambient air
atmospheric pollution
Air Pollutants
Nitrogen Dioxide
Pulmonary diseases
Hospitalization
Carbon Monoxide
Coastal zones
Logistics
Professional Practice
Aerodynamics
Hospital Records
International Classification of Diseases
respiratory disease
infant
Premature Infants

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

A case-crossover study of wintertime ambient air pollution and infant bronchiolitis. / Karr, Catherine; Lumley, Thomas; Shepherd, Kristen; Davis, Robert; Larson, Timothy; Ritz, Beate; Kaufman, Joel.

In: Environmental Health Perspectives, Vol. 114, No. 2, 01.02.2006, p. 277-281.

Research output: Contribution to journalArticle

Karr, C, Lumley, T, Shepherd, K, Davis, R, Larson, T, Ritz, B & Kaufman, J 2006, 'A case-crossover study of wintertime ambient air pollution and infant bronchiolitis', Environmental Health Perspectives, vol. 114, no. 2, pp. 277-281. https://doi.org/10.1289/ehp.8313
Karr, Catherine ; Lumley, Thomas ; Shepherd, Kristen ; Davis, Robert ; Larson, Timothy ; Ritz, Beate ; Kaufman, Joel. / A case-crossover study of wintertime ambient air pollution and infant bronchiolitis. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 2. pp. 277-281.
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