A case of disseminated histoplasmosis following autologous stem cell transplantation for Hodgkin's lymphoma

An initial misdiagnosis with a false-positive serum galactomannan assay

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Systemic histoplasmosis is uncommonly reported in patients who have undergone bone marrow or solid organ transplantation. Diagnosis of systemic histoplasmosis in recipients of transplants may be hampered by lack of consideration of this infection in the differential diagnosis and may be confounded by conflicting information from other testing performed to evaluate for opportunistic infections in this population. We report successful treatment of a case of disseminated histoplasmosis in a patient with Hodgkin's lymphoma who had undergone autologous stem cell transplantation. The diagnosis was delayed by the finding of a positive serum galactomannan assay.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalTransplant Infectious Disease
Volume11
Issue number3
DOIs
StatePublished - Jun 1 2009

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Histoplasmosis
Stem Cell Transplantation
Diagnostic Errors
Hodgkin Disease
Serum
Delayed Diagnosis
Opportunistic Infections
Organ Transplantation
Differential Diagnosis
Bone Marrow
Infection
Population
galactomannan
Therapeutics

All Science Journal Classification (ASJC) codes

  • Transplantation
  • Infectious Diseases

Cite this

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abstract = "Systemic histoplasmosis is uncommonly reported in patients who have undergone bone marrow or solid organ transplantation. Diagnosis of systemic histoplasmosis in recipients of transplants may be hampered by lack of consideration of this infection in the differential diagnosis and may be confounded by conflicting information from other testing performed to evaluate for opportunistic infections in this population. We report successful treatment of a case of disseminated histoplasmosis in a patient with Hodgkin's lymphoma who had undergone autologous stem cell transplantation. The diagnosis was delayed by the finding of a positive serum galactomannan assay.",
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AB - Systemic histoplasmosis is uncommonly reported in patients who have undergone bone marrow or solid organ transplantation. Diagnosis of systemic histoplasmosis in recipients of transplants may be hampered by lack of consideration of this infection in the differential diagnosis and may be confounded by conflicting information from other testing performed to evaluate for opportunistic infections in this population. We report successful treatment of a case of disseminated histoplasmosis in a patient with Hodgkin's lymphoma who had undergone autologous stem cell transplantation. The diagnosis was delayed by the finding of a positive serum galactomannan assay.

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