A comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model

S. A. Grant, C. R. Deeken, S. R. Hamilton, D. A. Grant, S. L. Bachman, Bruce Ramshaw

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The extracellular matrices of a variety of human and animal tissues have been utilized as scaffold materials for soft tissue applications including hernia repair, dermal grafts, and tendon, ligament, and cartilage reconstruction. While these biological scaffolds are expected to demonstrate superior tissue integration, there is very little evidence documenting the properties and behavior of these materials in vivo. This in vivo study investigated four biological scaffolds: two commercially available (a moderately crosslinked scaffold and a noncrosslinked scaffold) and two novel porcine diaphragm biological scaffolds (one with and one without the incorporation of gold nanoparticles). The scaffolds were implanted in a porcine model and evaluated over 1, 3, and 6 months. The moderately crosslinked scaffolds demonstrated the least cellular infiltration and evidence of fibrosis. The noncrosslinked scaffolds demonstrated the greatest cellular infiltration, but these scaffolds were delaminated and exhibited a rapid loss of integrity. The porcine diaphragm scaffolds with and without nanoparticles showed evidence of tissue remodeling and cellular infiltration, with no evidence of encapsulation. While there were no significant differences in the performance of the two novel scaffolds, the gold nanoparticle scaffold typically exhibited higher cellular infiltration. This study demonstrated the potential biocompatibility of a gold nanoparticle-tissue scaffold. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2778-2787, 2013.

Original languageEnglish (US)
Pages (from-to)2778-2787
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume101
Issue number10
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

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Tissue Scaffolds
Scaffolds
Infiltration
Gold
Tissue
Nanoparticles
Diaphragms
Ligaments
Tendons
Cartilage
Scaffolds (biology)
Biocompatibility
Encapsulation
Grafts

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

A comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model. / Grant, S. A.; Deeken, C. R.; Hamilton, S. R.; Grant, D. A.; Bachman, S. L.; Ramshaw, Bruce.

In: Journal of Biomedical Materials Research - Part A, Vol. 101, No. 10, 01.10.2013, p. 2778-2787.

Research output: Contribution to journalArticle

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