A comparison of immunologic asthma to two types of cholinergic respiratory responses in the rhesus monkey

Michael Miller, Roy Patterson, Kathleen E. Harris

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Rhesus monkeys were used to characterize the respiratory response (RR) to aerosolized physostigmine (Phy) and compare the response to the acute, reagin-mediated RR and the carbachol response. In the latter two responses, there are characteristic increases in frequency of respiration (f), pulmonary resistance (PR), and decreases in peak expiratory flow rate (PEFR), tidal volume (TV), and dynamic compliance (C). In contrast, a Phy RR characteristically shows no change in TV and f. The Phy RR is inhibited by atropine and lidocaine. The carbachol RR is inhibited by atropine but not lidocaine. The reagin-mediated RR is inhibited by neither lidocaine nor atropine. The Phy RR mimics a vagally induced RR more closely than carbachol because it is inhibited by pharmacologic and physiologic vagal blockade produced by atropine and lidocaine, respectively, whereas the carbachol RR is blocked by atropine but not lidocaine. The carbachol block by atropine is primarily not a block of vagal action, but a general pharmacologic block of cholinergic action. The reagin-mediated RR is not inhibited by pharmacologic or physiologic vagal blockade. We conclude that a Phy-induced vagomimetic RR differs from a reagin-mediated, immediate-type RR. Although a minor portion, at most, of a reagin-mediated, immediate-type RR may be mediated via the vagus nerve, the major portion of a reagin-mediated RR occurs independent of the influences of the parasympathetic innervation of the lung.

Original languageEnglish (US)
Pages (from-to)995-1007
Number of pages13
JournalThe Journal of Laboratory and Clinical Medicine
Volume88
Issue number6
StatePublished - Jan 1 1976
Externally publishedYes

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Reagins
Physostigmine
Macaca mulatta
Atropine
Cholinergic Agents
Carbachol
Lidocaine
Asthma
Tidal Volume
Peak Expiratory Flow Rate
Lung
Vagus Nerve
Compliance
Respiration
Flow rate

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

A comparison of immunologic asthma to two types of cholinergic respiratory responses in the rhesus monkey. / Miller, Michael; Patterson, Roy; Harris, Kathleen E.

In: The Journal of Laboratory and Clinical Medicine, Vol. 88, No. 6, 01.01.1976, p. 995-1007.

Research output: Contribution to journalArticle

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