A comparison of peripheral and central human muscarinic cholinergic receptor affinities for psychotropic drugs

G. D. Tollefson, Susan Senogles, W. H. Frey, V. B. Tuason, S. E. Nicol

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A peripheral model offers a valuable research tool for the investigation of central cholinopathic disorders. The in vitro affinities of several psychotropic drugs for the muscarinic cholinergic binding sites of human caudate and erythrocyte were compared in competition with a tritiated antagonist (quinuclidinyl benzilate). The relative affinities of the drugs for both tissues were strikingly similar. Thus, the erythrocyte muscarinic receptor may represent an accessible in vitro assay for the characterization of central cholinopathic states.

Original languageEnglish (US)
Pages (from-to)555-567
Number of pages13
JournalBiological Psychiatry
Volume17
Issue number5
StatePublished - 1982

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Psychotropic Drugs
Cholinergic Receptors
Muscarinic Receptors
Cholinergic Agents
Erythrocytes
Quinuclidinyl Benzilate
Binding Sites
Research
Pharmaceutical Preparations
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

A comparison of peripheral and central human muscarinic cholinergic receptor affinities for psychotropic drugs. / Tollefson, G. D.; Senogles, Susan; Frey, W. H.; Tuason, V. B.; Nicol, S. E.

In: Biological Psychiatry, Vol. 17, No. 5, 1982, p. 555-567.

Research output: Contribution to journalArticle

Tollefson, G. D. ; Senogles, Susan ; Frey, W. H. ; Tuason, V. B. ; Nicol, S. E. / A comparison of peripheral and central human muscarinic cholinergic receptor affinities for psychotropic drugs. In: Biological Psychiatry. 1982 ; Vol. 17, No. 5. pp. 555-567.
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