A comparison of the sensitivities of neonatal ovine pulmonary and femoral arteries to l-norepinephrine stimulation

Robert S. Green, Charles Leffler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We compared the concentration-response relationship of intralobar pulmonary arteries to l –norepinephrine with that of femoral arteries from newborn lambs. In addition, the effect of inhibition of the neuronal and extra-neuronal uptake mechanisms on these concentration-response relationships was examined. Concentration-response curves on 10 intralobar pulmonary arteries were performed with and without inhibition of the uptake mechanisms. Uptake inhibition shifts the curve to the left; thus, the -log EC50 with uptake inhibition (6.63 ± 0.15) is greater than that without uptake inhibition (6.13 ± 0.14). Similar curves on 10 femoral arteries demonstrated that the -log EC50 with and without uptake inhibition (6.20 ± 0.13 and 6.00 ± 0.04, respectively) are not statistically different. Because, in the presence of intact uptake mechanisms the concentration of l –norepinephrine in the a-receptor microenvironment is less than that placed in the organ bath, the appropriate comparison of pulmonary and femoral arterial response to l– norepinephrine stimulation requires uptake inhibition in both vessels. The concentration-response curve with uptake inhibition for the intralobar pulmonary artery is significantly to the left of that for the femoral; the -log EC50 for the pulmonary vessel (6.63 ± 0.15) is greater than that of the femoral vessel (6.20 ± 0.13). The intralobar pulmonary artery in vitro is more sensitive to l-norepinephrine stimulation than is the femoral.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalPediatric Research
Volume18
Issue number3
DOIs
StatePublished - Jan 1 1984

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Femoral Artery
Thigh
Pulmonary Artery
Sheep
Norepinephrine
Lung
Baths

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

A comparison of the sensitivities of neonatal ovine pulmonary and femoral arteries to l-norepinephrine stimulation. / Green, Robert S.; Leffler, Charles.

In: Pediatric Research, Vol. 18, No. 3, 01.01.1984, p. 244-247.

Research output: Contribution to journalArticle

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