A contemporary update on pathology standards for bladder cancer

Transurethral resection and radical cystectomy specimens

Donna E. Hansel, Mahul Amin, Eva Comperat, Richard J. Cote, Ruth Knüchel, Rodolfo Montironi, Victor E. Reuter, Mark S. Soloway, Saleem A. Umar, Theodorus H. Van Der Kwast

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting as of June 6, 2012. We also reviewed the proceedings from the recent Second International Consultation on Bladder Cancer (Vienna, Austria). The literature selected for review focuses on evidence-based studies that address histopathologic factors in BCa, with emphasis placed on factors that influence patient diagnosis and clinical outcomes. Evidence synthesis: We separated data into three main components for analysis based on the type of specimen obtained: (1) transurethral resection specimens, with an emphasis on pathologic staging, variants of urothelial carcinoma, angiolymphatic invasion, and relevant ancillary techniques such as immunohistochemistry in assessing these features; (2) cystectomy specimens, with an emphasis on pT0 disease, prostatic involvement by urothelial carcinoma and lymph node dissection and analysis; and (3) cytology correlates, with recommendations for the use of cytology paired with tissue-based sampling. Areas of controversy are described and recommendations based on existing guidelines are provided. The value of a multidisciplinary team is highlighted. Conclusions: Ongoing international collaborations amongst pathologists have led to emerging standards in the reporting and microscopic diagnosis of BCa specimens. Although some areas remain controversial, we present the most up-to-date data and guidelines relevant to neoplastic pathology of the urinary bladder.

Original languageEnglish (US)
Pages (from-to)321-332
Number of pages12
JournalEuropean Urology
Volume63
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Fingerprint

Cystectomy
Urinary Bladder Neoplasms
Pathology
Cell Biology
Prostatic Diseases
Guidelines
Carcinoma
Austria
Lymph Node Excision
Dissection
Urinary Bladder
Referral and Consultation
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

A contemporary update on pathology standards for bladder cancer : Transurethral resection and radical cystectomy specimens. / Hansel, Donna E.; Amin, Mahul; Comperat, Eva; Cote, Richard J.; Knüchel, Ruth; Montironi, Rodolfo; Reuter, Victor E.; Soloway, Mark S.; Umar, Saleem A.; Van Der Kwast, Theodorus H.

In: European Urology, Vol. 63, No. 2, 01.02.2013, p. 321-332.

Research output: Contribution to journalReview article

Hansel, DE, Amin, M, Comperat, E, Cote, RJ, Knüchel, R, Montironi, R, Reuter, VE, Soloway, MS, Umar, SA & Van Der Kwast, TH 2013, 'A contemporary update on pathology standards for bladder cancer: Transurethral resection and radical cystectomy specimens', European Urology, vol. 63, no. 2, pp. 321-332. https://doi.org/10.1016/j.eururo.2012.10.008
Hansel, Donna E. ; Amin, Mahul ; Comperat, Eva ; Cote, Richard J. ; Knüchel, Ruth ; Montironi, Rodolfo ; Reuter, Victor E. ; Soloway, Mark S. ; Umar, Saleem A. ; Van Der Kwast, Theodorus H. / A contemporary update on pathology standards for bladder cancer : Transurethral resection and radical cystectomy specimens. In: European Urology. 2013 ; Vol. 63, No. 2. pp. 321-332.
@article{faa48c43f865484882ea95ffbae00ef0,
title = "A contemporary update on pathology standards for bladder cancer: Transurethral resection and radical cystectomy specimens",
abstract = "Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting as of June 6, 2012. We also reviewed the proceedings from the recent Second International Consultation on Bladder Cancer (Vienna, Austria). The literature selected for review focuses on evidence-based studies that address histopathologic factors in BCa, with emphasis placed on factors that influence patient diagnosis and clinical outcomes. Evidence synthesis: We separated data into three main components for analysis based on the type of specimen obtained: (1) transurethral resection specimens, with an emphasis on pathologic staging, variants of urothelial carcinoma, angiolymphatic invasion, and relevant ancillary techniques such as immunohistochemistry in assessing these features; (2) cystectomy specimens, with an emphasis on pT0 disease, prostatic involvement by urothelial carcinoma and lymph node dissection and analysis; and (3) cytology correlates, with recommendations for the use of cytology paired with tissue-based sampling. Areas of controversy are described and recommendations based on existing guidelines are provided. The value of a multidisciplinary team is highlighted. Conclusions: Ongoing international collaborations amongst pathologists have led to emerging standards in the reporting and microscopic diagnosis of BCa specimens. Although some areas remain controversial, we present the most up-to-date data and guidelines relevant to neoplastic pathology of the urinary bladder.",
author = "Hansel, {Donna E.} and Mahul Amin and Eva Comperat and Cote, {Richard J.} and Ruth Kn{\"u}chel and Rodolfo Montironi and Reuter, {Victor E.} and Soloway, {Mark S.} and Umar, {Saleem A.} and {Van Der Kwast}, {Theodorus H.}",
year = "2013",
month = "2",
day = "1",
doi = "10.1016/j.eururo.2012.10.008",
language = "English (US)",
volume = "63",
pages = "321--332",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A contemporary update on pathology standards for bladder cancer

T2 - Transurethral resection and radical cystectomy specimens

AU - Hansel, Donna E.

AU - Amin, Mahul

AU - Comperat, Eva

AU - Cote, Richard J.

AU - Knüchel, Ruth

AU - Montironi, Rodolfo

AU - Reuter, Victor E.

AU - Soloway, Mark S.

AU - Umar, Saleem A.

AU - Van Der Kwast, Theodorus H.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting as of June 6, 2012. We also reviewed the proceedings from the recent Second International Consultation on Bladder Cancer (Vienna, Austria). The literature selected for review focuses on evidence-based studies that address histopathologic factors in BCa, with emphasis placed on factors that influence patient diagnosis and clinical outcomes. Evidence synthesis: We separated data into three main components for analysis based on the type of specimen obtained: (1) transurethral resection specimens, with an emphasis on pathologic staging, variants of urothelial carcinoma, angiolymphatic invasion, and relevant ancillary techniques such as immunohistochemistry in assessing these features; (2) cystectomy specimens, with an emphasis on pT0 disease, prostatic involvement by urothelial carcinoma and lymph node dissection and analysis; and (3) cytology correlates, with recommendations for the use of cytology paired with tissue-based sampling. Areas of controversy are described and recommendations based on existing guidelines are provided. The value of a multidisciplinary team is highlighted. Conclusions: Ongoing international collaborations amongst pathologists have led to emerging standards in the reporting and microscopic diagnosis of BCa specimens. Although some areas remain controversial, we present the most up-to-date data and guidelines relevant to neoplastic pathology of the urinary bladder.

AB - Context: Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes. Objective: To update pathology reporting standards for BCa. Evidence acquisition: We searched the international medical literature and reviewed all articles that addressed BCa gross dissection, pathologic diagnosis, staging, and reporting as of June 6, 2012. We also reviewed the proceedings from the recent Second International Consultation on Bladder Cancer (Vienna, Austria). The literature selected for review focuses on evidence-based studies that address histopathologic factors in BCa, with emphasis placed on factors that influence patient diagnosis and clinical outcomes. Evidence synthesis: We separated data into three main components for analysis based on the type of specimen obtained: (1) transurethral resection specimens, with an emphasis on pathologic staging, variants of urothelial carcinoma, angiolymphatic invasion, and relevant ancillary techniques such as immunohistochemistry in assessing these features; (2) cystectomy specimens, with an emphasis on pT0 disease, prostatic involvement by urothelial carcinoma and lymph node dissection and analysis; and (3) cytology correlates, with recommendations for the use of cytology paired with tissue-based sampling. Areas of controversy are described and recommendations based on existing guidelines are provided. The value of a multidisciplinary team is highlighted. Conclusions: Ongoing international collaborations amongst pathologists have led to emerging standards in the reporting and microscopic diagnosis of BCa specimens. Although some areas remain controversial, we present the most up-to-date data and guidelines relevant to neoplastic pathology of the urinary bladder.

UR - http://www.scopus.com/inward/record.url?scp=84871920558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871920558&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2012.10.008

DO - 10.1016/j.eururo.2012.10.008

M3 - Review article

VL - 63

SP - 321

EP - 332

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 2

ER -