A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones

Solomon S. Solomon, Gipsy Majumdar, Antonio Martinez-Hernandez, Rajendra Raghow

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

Specificity protein 1 (Sp1) belongs to a family of ubiquitously expressed, C2H2-type zinc finger-containing DNA binding proteins that activate or repress transcription of many genes in response to physiological and pathological stimuli. There is emerging evidence to indicate that in addition to functioning as 'housekeeping' transcription factors, members of Sp family may be key mediators of gene expression induced by insulin and other hormones. The founding member of the family, Sp1, by virtue of its multi-domain organization, potential for posttranslational modifications and interactions with numerous transcription factors, represents an ideal mediator of nuclear signaling in response to hormones. Insulin regulates the sub-cellular localization, stability and trans-activation potential of Sp1 by dynamically modulating its post-translational modification by O-linked β-N-acetylglucosamine (O-GlcNAc) or phosphate residues. We briefly review the recent literature demonstrating that an involvement of Sp-family of transcription factors in the regulation of differential gene expression in response to hormones is more common than previously appreciated and may represent a key regulatory mechanism.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalLife Sciences
Volume83
Issue number9-10
DOIs
StatePublished - Aug 29 2008

Fingerprint

Sp1 Transcription Factor
Gene expression
Sp Transcription Factors
Transcription Factors
Hormones
Insulin
Gene Expression
Post Translational Protein Processing
Proteins
Acetylglucosamine
DNA-Binding Proteins
Transcription
Housekeeping
Zinc
Gene Expression Regulation
Genes
Chemical activation
Phosphates

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones. / Solomon, Solomon S.; Majumdar, Gipsy; Martinez-Hernandez, Antonio; Raghow, Rajendra.

In: Life Sciences, Vol. 83, No. 9-10, 29.08.2008, p. 305-312.

Research output: Contribution to journalReview article

Solomon, Solomon S. ; Majumdar, Gipsy ; Martinez-Hernandez, Antonio ; Raghow, Rajendra. / A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones. In: Life Sciences. 2008 ; Vol. 83, No. 9-10. pp. 305-312.
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