A discrete cell migration model

James Nutaro, Kara Kruse, Richard Ward, Elizabeth O'Quinn, Matthew Woerner, Barbara Beckerman, Stacy Kirkpatrick, Deidra Mountain, Oscar Grandas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Migration of vascular smooth muscle cells is a fundamental process in the development of intimal hyperplasia, a precursor to development of cardiovascular disease and a potential response to injury of an arterial wall. Boyden chamber experiments are used to quantify the motion of cell populations in response to a chemoattractant gradient (i.e., cell chemotaxis). We are developing a mathematical model of cell migration within the Boyden chamber, while simultaneously conducting experiments to obtain parameter values for the migration process. In the future, the model and parameters will be used as building blocks for a detailed model of the process that causes intimal hyperplasia. The cell migration model presented in this paper is based on the notion of a cell as a moving sensor that responds to an evolving chemoattractant gradient. We compare the results of our three-dimensional hybrid modelwith results from a one-dimensional continuummodel. Some preliminary experimental data that is being used to refine the model is also presented.

Original languageEnglish (US)
Title of host publicationSummer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07
Pages811-816
Number of pages6
Volume2
StatePublished - 2007
EventSummer Computer Simulation Conference 2007, SCSC 2007, Part of the 2007 Summer Simulation Multiconference, SummerSim 2007 - San Diego, CA, United States
Duration: Jul 15 2007Jul 18 2007

Other

OtherSummer Computer Simulation Conference 2007, SCSC 2007, Part of the 2007 Summer Simulation Multiconference, SummerSim 2007
CountryUnited States
CitySan Diego, CA
Period7/15/077/18/07

Fingerprint

Cell Migration
Migration
Vascular Smooth muscle
Cells
Smooth muscle Cells
Gradient
Chemotaxis
Cell Population
Cell
Precursor
Model
Building Blocks
Experiment
Muscle
Quantify
Experiments
Experimental Data
Mathematical Model
Mathematical models
Sensor

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation

Cite this

Nutaro, J., Kruse, K., Ward, R., O'Quinn, E., Woerner, M., Beckerman, B., ... Grandas, O. (2007). A discrete cell migration model. In Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07 (Vol. 2, pp. 811-816)

A discrete cell migration model. / Nutaro, James; Kruse, Kara; Ward, Richard; O'Quinn, Elizabeth; Woerner, Matthew; Beckerman, Barbara; Kirkpatrick, Stacy; Mountain, Deidra; Grandas, Oscar.

Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07. Vol. 2 2007. p. 811-816.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nutaro, J, Kruse, K, Ward, R, O'Quinn, E, Woerner, M, Beckerman, B, Kirkpatrick, S, Mountain, D & Grandas, O 2007, A discrete cell migration model. in Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07. vol. 2, pp. 811-816, Summer Computer Simulation Conference 2007, SCSC 2007, Part of the 2007 Summer Simulation Multiconference, SummerSim 2007, San Diego, CA, United States, 7/15/07.
Nutaro J, Kruse K, Ward R, O'Quinn E, Woerner M, Beckerman B et al. A discrete cell migration model. In Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07. Vol. 2. 2007. p. 811-816
Nutaro, James ; Kruse, Kara ; Ward, Richard ; O'Quinn, Elizabeth ; Woerner, Matthew ; Beckerman, Barbara ; Kirkpatrick, Stacy ; Mountain, Deidra ; Grandas, Oscar. / A discrete cell migration model. Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07. Vol. 2 2007. pp. 811-816
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