A formalin-inactivated whole SIV vaccine confers protection in macaques

Michael Murphey-Corb, Louis N. Martin, Billie Davison-Fairburn, Ronald C. Montelaro, Mark Miller, Melanie West, Susumu Ohkawa, Gary B. Baskin, Jing Yu Zhang, Scott D. Putney, Anthony C. Allison, Deborah A. Eppstein

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

A vaccine against human immunodeficiency virus (HIV) would be highly effective in stopping the acquired immunodeficiency syndrome (AIDS) epidemic. A comprehensive evaluation of potential vaccine methodologies can be made by means of the simian model for AIDS, which takes advantage of the similarities in viral composition and disease potential between simian inmunodeficency virus (SIV) infection of rhesus macaques and HIV infection in humans. Immunization with a formalin-inactivated whole SIV vaccine potentiated with either alum and the Syntex adjuvant threonyl muramyl dipeptide (MDP) or MDP alone resulted in the protection of eight of nine rhesus monkeys challenged with ten animal-infectious doses of pathogenic virus. These results demonstrate that a whole virus vaccine is highly effective in inducing immune responses that can protect against lentivirus infection and AIDS-like disease.

Original languageEnglish (US)
Pages (from-to)1293-1297
Number of pages5
JournalScience
Volume246
Issue number4935
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Macaca
Formaldehyde
Virus Diseases
Vaccines
Acetylmuramyl-Alanyl-Isoglutamine
Viruses
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
Lentivirus Infections
HIV
Immunization

All Science Journal Classification (ASJC) codes

  • General

Cite this

Murphey-Corb, M., Martin, L. N., Davison-Fairburn, B., Montelaro, R. C., Miller, M., West, M., ... Eppstein, D. A. (1989). A formalin-inactivated whole SIV vaccine confers protection in macaques. Science, 246(4935), 1293-1297. https://doi.org/10.1126/science.2555923

A formalin-inactivated whole SIV vaccine confers protection in macaques. / Murphey-Corb, Michael; Martin, Louis N.; Davison-Fairburn, Billie; Montelaro, Ronald C.; Miller, Mark; West, Melanie; Ohkawa, Susumu; Baskin, Gary B.; Zhang, Jing Yu; Putney, Scott D.; Allison, Anthony C.; Eppstein, Deborah A.

In: Science, Vol. 246, No. 4935, 01.01.1989, p. 1293-1297.

Research output: Contribution to journalArticle

Murphey-Corb, M, Martin, LN, Davison-Fairburn, B, Montelaro, RC, Miller, M, West, M, Ohkawa, S, Baskin, GB, Zhang, JY, Putney, SD, Allison, AC & Eppstein, DA 1989, 'A formalin-inactivated whole SIV vaccine confers protection in macaques', Science, vol. 246, no. 4935, pp. 1293-1297. https://doi.org/10.1126/science.2555923
Murphey-Corb M, Martin LN, Davison-Fairburn B, Montelaro RC, Miller M, West M et al. A formalin-inactivated whole SIV vaccine confers protection in macaques. Science. 1989 Jan 1;246(4935):1293-1297. https://doi.org/10.1126/science.2555923
Murphey-Corb, Michael ; Martin, Louis N. ; Davison-Fairburn, Billie ; Montelaro, Ronald C. ; Miller, Mark ; West, Melanie ; Ohkawa, Susumu ; Baskin, Gary B. ; Zhang, Jing Yu ; Putney, Scott D. ; Allison, Anthony C. ; Eppstein, Deborah A. / A formalin-inactivated whole SIV vaccine confers protection in macaques. In: Science. 1989 ; Vol. 246, No. 4935. pp. 1293-1297.
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