A genetic and genomic approach to identify longevity genes in mice

Gerald De Haan, Robert Williams

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Natural variation in rate of aging or longevity in mice and humans shows a very complex inheritance pattern. Few targeted genetic screens have identified longevity genes in mammals, partly as a result from the fact that the genetics of longevity can only be studied reliably in cohorts of mice. In this paper we propose that a combined genetic and genomic analysis of large families of fully genotyped recombinant inbred mice may provide a crucial tool to the aging research community. As a proof of principle we describe preliminary studies in which variation in gene expression patterns in hematopoietic stem cells and brain were genetically linked to longevity.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalMechanisms of Ageing and Development
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Genes
Aging of materials
Mammals
Stem cells
Gene expression
Brain
Inheritance Patterns
Hematopoietic Stem Cells
Gene Expression
Research
Genetics

All Science Journal Classification (ASJC) codes

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

A genetic and genomic approach to identify longevity genes in mice. / Haan, Gerald De; Williams, Robert.

In: Mechanisms of Ageing and Development, Vol. 126, No. 1, 01.01.2005, p. 133-138.

Research output: Contribution to journalArticle

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