A high-dosage fluconazole therapy in a patient with Rhodotorula pilimanae fungemia

John D. Cleary, Tanya M. Oswald, Phillip Rogers, Anne Whitehurst

Research output: Contribution to journalArticle

Abstract

Objective: To describe a case of Rhodotorula pilimanae fungemia in a middle aged female patient that responded to treatment with high dose fluconazole. Case Summary: A 48-year-old black female patient was admitted to the hospital for treatment of acute pancreatitis. Diagnosis of fungemia was based on an isolation of the yeast from one of two peripheral blood cultures collected on hospital day 10. Therapy with 800 mg (12 mg/kg/d) fluconazole daily for 19 days was successful in eliminating the yeast. Following fluconazole treatment; blood, urine, and stool cultures had no growth of R. pilimanae. The patient showed no evidence of recurrence after 2 weeks of follow-up. Discussion: Rhodotorula is a genus of coral-red yeasts in the family Cryptococcaceae, subfamily Rhodotorulodeae. The organisms are widespread in nature. They can be found in the air, sea water, plant materials, as well as on the skin, nails, conjunctiva, and the respiratory, gastrointestinal, and urinary tracts of humans. They are typically non-pathogenic, however, Rhodotorula species may cause infection and can be lifethreatening. Most infections caused by Rhodotorula species have been associated with intravenous catheters and patients with solid tumors, lymphoproliferative diseases, chronic renal failure, AIDS, and diabetes mellitus. The treatment of infections due to Rhodotorula species is controversial. They have been successfully treated pharmacologically with amphotericin B and 5-flurocytosine. Conclusions: This case suggests that in susceptible Rhodotorula species, infection can be successfully treated with high dose fluconazole.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalJournal of Infectious Disease Pharmacotherapy
Volume4
Issue number3
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

Fungemia
Rhodotorula
Fluconazole
Yeasts
Infection
Therapeutics
Anthozoa
Conjunctiva
Seawater
Amphotericin B
Nails
Urinary Tract
Pancreatitis
Respiratory System
Chronic Kidney Failure
Gastrointestinal Tract
Diabetes Mellitus
Acquired Immunodeficiency Syndrome
Catheters
Air

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)

Cite this

A high-dosage fluconazole therapy in a patient with Rhodotorula pilimanae fungemia. / Cleary, John D.; Oswald, Tanya M.; Rogers, Phillip; Whitehurst, Anne.

In: Journal of Infectious Disease Pharmacotherapy, Vol. 4, No. 3, 01.12.2001, p. 73-82.

Research output: Contribution to journalArticle

Cleary, John D. ; Oswald, Tanya M. ; Rogers, Phillip ; Whitehurst, Anne. / A high-dosage fluconazole therapy in a patient with Rhodotorula pilimanae fungemia. In: Journal of Infectious Disease Pharmacotherapy. 2001 ; Vol. 4, No. 3. pp. 73-82.
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