A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women

Qi Zhao, Hui Shen, Kuan Jui Su, Qing Tian, Lan Juan Zhao, Chuan Qiu, Timothy J. Garrett, Jiawang Liu, David Kakhniashvili, Hong Wen Deng

Research output: Contribution to journalArticle

Abstract

Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.

Original languageEnglish (US)
Pages (from-to)2624-2635
Number of pages12
JournalAging
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Metabolomics
Muscle Strength
Hand Strength
Hydroxyeicosatetraenoic Acids
Aspartic Acid
Sarcopenia
Amino Acids
Glutamic Acid
Arachidonic Acid
Lipids
Muscles
Threonine
Metabolic Networks and Pathways
Liquid Chromatography
Mass Spectrometry
Body Mass Index
Multivariate Analysis
Carbohydrates
Peptides
Serum

All Science Journal Classification (ASJC) codes

  • Aging
  • Cell Biology

Cite this

Zhao, Q., Shen, H., Su, K. J., Tian, Q., Zhao, L. J., Qiu, C., ... Deng, H. W. (2018). A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women. Aging, 10(10), 2624-2635. https://doi.org/10.18632/aging.101574

A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women. / Zhao, Qi; Shen, Hui; Su, Kuan Jui; Tian, Qing; Zhao, Lan Juan; Qiu, Chuan; Garrett, Timothy J.; Liu, Jiawang; Kakhniashvili, David; Deng, Hong Wen.

In: Aging, Vol. 10, No. 10, 01.10.2018, p. 2624-2635.

Research output: Contribution to journalArticle

Zhao, Q, Shen, H, Su, KJ, Tian, Q, Zhao, LJ, Qiu, C, Garrett, TJ, Liu, J, Kakhniashvili, D & Deng, HW 2018, 'A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women', Aging, vol. 10, no. 10, pp. 2624-2635. https://doi.org/10.18632/aging.101574
Zhao, Qi ; Shen, Hui ; Su, Kuan Jui ; Tian, Qing ; Zhao, Lan Juan ; Qiu, Chuan ; Garrett, Timothy J. ; Liu, Jiawang ; Kakhniashvili, David ; Deng, Hong Wen. / A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women. In: Aging. 2018 ; Vol. 10, No. 10. pp. 2624-2635.
@article{7ba31addb20c478d9b94560a1f1c5f51,
title = "A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women",
abstract = "Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.",
author = "Qi Zhao and Hui Shen and Su, {Kuan Jui} and Qing Tian and Zhao, {Lan Juan} and Chuan Qiu and Garrett, {Timothy J.} and Jiawang Liu and David Kakhniashvili and Deng, {Hong Wen}",
year = "2018",
month = "10",
day = "1",
doi = "10.18632/aging.101574",
language = "English (US)",
volume = "10",
pages = "2624--2635",
journal = "Aging",
issn = "0002-0966",
publisher = "US Administration on Aging",
number = "10",

}

TY - JOUR

T1 - A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women

AU - Zhao, Qi

AU - Shen, Hui

AU - Su, Kuan Jui

AU - Tian, Qing

AU - Zhao, Lan Juan

AU - Qiu, Chuan

AU - Garrett, Timothy J.

AU - Liu, Jiawang

AU - Kakhniashvili, David

AU - Deng, Hong Wen

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.

AB - Both loss of muscle mass and strength are important sarcopenia-related traits. In this study, we investigated both specific and shared serum metabolites associated with these two traits in 136 Caucasian women using a liquid chromatography-mass spectrometry method. A joint analysis of multivariate traits was used to examine the associations of individual metabolites with muscle mass measured by the body mass index-adjusted appendicular lean mass (ALM/BMI) and muscle strength measured by hand grip strength (HGS). After adjusting for multiple testing, nine metabolites including two amino acids (aspartic acid and glutamic acid) and an amino acid derive (pipecolic acid), one peptide (phenylalanyl-threonine), one carbohydrate (methyl beta-D-glucopyranoside), and four lipids (12S-HETRE, arachidonic acid, 12S-HETE, and glycerophosphocholine) were significant in the joint analysis. Of them, the two amino acids (aspartic acid and glutamic acid) and two lipids (12S-HETRE and 12S-HETE) were associated with both ALM/BMI and HGS, and the other five were only associated with ALM/BMI. The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.

UR - http://www.scopus.com/inward/record.url?scp=85055905549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055905549&partnerID=8YFLogxK

U2 - 10.18632/aging.101574

DO - 10.18632/aging.101574

M3 - Article

VL - 10

SP - 2624

EP - 2635

JO - Aging

JF - Aging

SN - 0002-0966

IS - 10

ER -