A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo

Yuanyuan Jiao, Zhi Zhang, Chunzhao Zhang, Xinjun Wang, Kazuko Sakata, Bai Lu, Qian Quan Sun

Research output: Contribution to journalArticle

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Abstract

Mechanisms underlying experience-dependent refinement of cortical connections, especially GABAergic inhibitory circuits, are unknown. By using a line of mutant mice that lack activity-dependent BDNF expression (bdnf-KIV), we show that experience regulation of cortical GABAergic network is mediated by activity-driven BDNF expression. Levels of endogenous BDNF protein in the barrel cortex are strongly regulated by sensory inputs from whiskers. There is a severe alteration of excitation and inhibition balance in the barrel cortex of bdnf-KIV mice as a result of reduced inhibitory but not excitatory conductance. Within the inhibitory circuits, the mutant barrel cortex exhibits significantly reduced levels of GABA release only from the parvalbumin-expressing fast-spiking (FS) interneurons, but not other interneuron subtypes. Postnatal deprivation of sensory inputs markedly decreased perisomatic inhibition selectively from FS cells in wild-type but not bdnf-KIV mice. These results suggest that postnatal experience, through activity-driven BDNF expression, controls cortical development by regulating FS cell-mediated perisomatic inhibition in vivo.

Original languageEnglish (US)
Pages (from-to)12131-12136
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number29
DOIs
StatePublished - Jul 19 2011

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Brain-Derived Neurotrophic Factor
Interneurons
Sensory Deprivation
Vibrissae
Parvalbumins
gamma-Aminobutyric Acid
Inhibition (Psychology)
Proteins

All Science Journal Classification (ASJC) codes

  • General

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A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. / Jiao, Yuanyuan; Zhang, Zhi; Zhang, Chunzhao; Wang, Xinjun; Sakata, Kazuko; Lu, Bai; Sun, Qian Quan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 29, 19.07.2011, p. 12131-12136.

Research output: Contribution to journalArticle

Jiao, Yuanyuan ; Zhang, Zhi ; Zhang, Chunzhao ; Wang, Xinjun ; Sakata, Kazuko ; Lu, Bai ; Sun, Qian Quan. / A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. 29. pp. 12131-12136.
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