A long-term intensive lifestyle intervention and physical function

The look AHEAD Movement and Memory Study

Denise K. Houston, Xiaoyan Leng, George A. Bray, Andrea L. Hergenroeder, James O. Hill, John M. Jakicic, Karen Johnson, Rebecca H. Neiberg, Anthony P. Marsh, W. Jack Rejeski, Stephen B. Kritchevsky

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective To assess the long-term effects of an intensive lifestyle intervention on physical function using a randomized post-test design in the Look AHEAD trial. Methods Overweight and obese (BMI ≥ 25 kg m-2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes (n = 964) at four clinics in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including an expanded short physical performance battery (SPPBexp), 20-m and 400-m walk, and grip and knee extensor strength 8 years post-randomization, during the trial's weight maintenance phase. Results Eight years post-randomization, individuals randomized to ILI had better SPPBexp scores [adjusted mean (SE) difference: 0.055 (0.022), P = 0.01] and faster 20-m and 400-m walk speeds [0.032 (0.012) m s-1, P = 0.01, and 0.025 (0.011) m s-1, P = 0.02, respectively] compared to those randomized to DSE. Achieved weight loss greatly attenuated the group differences in physical function, and the intervention effect was no longer significant. Conclusions An intensive lifestyle intervention has long-term benefits for mobility function in overweight and obese middle-aged and older individuals with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalObesity
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2015

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Life Style
Random Allocation
Type 2 Diabetes Mellitus
Weight Loss
Education
Caloric Restriction
Hand Strength
Knee
Maintenance
Exercise
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Houston, D. K., Leng, X., Bray, G. A., Hergenroeder, A. L., Hill, J. O., Jakicic, J. M., ... Kritchevsky, S. B. (2015). A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory Study. Obesity, 23(1), 77-84. https://doi.org/10.1002/oby.20944

A long-term intensive lifestyle intervention and physical function : The look AHEAD Movement and Memory Study. / Houston, Denise K.; Leng, Xiaoyan; Bray, George A.; Hergenroeder, Andrea L.; Hill, James O.; Jakicic, John M.; Johnson, Karen; Neiberg, Rebecca H.; Marsh, Anthony P.; Rejeski, W. Jack; Kritchevsky, Stephen B.

In: Obesity, Vol. 23, No. 1, 01.01.2015, p. 77-84.

Research output: Contribution to journalArticle

Houston, DK, Leng, X, Bray, GA, Hergenroeder, AL, Hill, JO, Jakicic, JM, Johnson, K, Neiberg, RH, Marsh, AP, Rejeski, WJ & Kritchevsky, SB 2015, 'A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory Study', Obesity, vol. 23, no. 1, pp. 77-84. https://doi.org/10.1002/oby.20944
Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM et al. A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory Study. Obesity. 2015 Jan 1;23(1):77-84. https://doi.org/10.1002/oby.20944
Houston, Denise K. ; Leng, Xiaoyan ; Bray, George A. ; Hergenroeder, Andrea L. ; Hill, James O. ; Jakicic, John M. ; Johnson, Karen ; Neiberg, Rebecca H. ; Marsh, Anthony P. ; Rejeski, W. Jack ; Kritchevsky, Stephen B. / A long-term intensive lifestyle intervention and physical function : The look AHEAD Movement and Memory Study. In: Obesity. 2015 ; Vol. 23, No. 1. pp. 77-84.
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