A magnetically actuated left ventricular assist device

S. G. Kovacs, D. G. Reynolds, Peter Mckeown, P. G. Augereau, J. A. Wasselle, L. E. Ondrovic, M. Aiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Over the past 6 years, research has led to development of a small, lightweight, power-efficient, uniquely simple ventricular assist device driven by a magnetic actuator. Magnetic actuation permits total elimination of all mechanical motion converter components used for pusher plate displacement, resulting in a significant reduction in complexity and resultant increase in reliability. Extensive in vitro mock loop development has resulted in a left ventricular assist device (LVAD), the primary design parameters of which for the clinical prototype actuator and pump are 1) an actuator weight of 312 g, 2) actuator size of 32.5 cm3, 3) power requirements of 7.8 to 11.4 watts (60-100 beats per minute [BPM]), and 4) system efficiency of 24% to 34% and average dynamic stroke volume of 65 ml. Initial in vivo tests assessed this LVAD's performance in four sheep under three acute conditions of ventricular dysfunction. The results demonstrate that, at a pump-rate of 100 BPM, mean aortic pressure increased by 45-50 mmHg during 1) beta blockade, 2) coronary ligation, and 3) ventricular fibrillation. Pump flow ranged from 2.71 L/min to a maximum of 4.6 L/min. Acute test periods were arbitrarily set for 6 hours duration. Of the four sheep, two survived, one lived 5 hours, and the fourth lived 4.5 hours. Global fibrillation was the primary cause of failure. This initial in vivo data demonstrates the pump's ability to maintain satisfactory hemodynamic parameters of flow and pressure under three acute conditions of extreme left ventricular dysfunction in an animal model. These initial LVAD performances were encouraging. Further tests will use calves with a greatly expanded performance evaluation protocol.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalASAIO Journal
Volume38
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Left ventricular assist devices
Heart-Assist Devices
Pumps
Actuators
Sheep
Equipment Design
Ventricular Dysfunction
Magnetic actuators
Left Ventricular Dysfunction
Ventricular Fibrillation
Stroke Volume
Ligation
Arterial Pressure
Hemodynamics
Animal Models
Pressure
Weights and Measures
Animals
Research

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Kovacs, S. G., Reynolds, D. G., Mckeown, P., Augereau, P. G., Wasselle, J. A., Ondrovic, L. E., & Aiba, M. (1992). A magnetically actuated left ventricular assist device. ASAIO Journal, 38(1), 38-46. https://doi.org/10.1097/00002480-199201000-00010

A magnetically actuated left ventricular assist device. / Kovacs, S. G.; Reynolds, D. G.; Mckeown, Peter; Augereau, P. G.; Wasselle, J. A.; Ondrovic, L. E.; Aiba, M.

In: ASAIO Journal, Vol. 38, No. 1, 01.01.1992, p. 38-46.

Research output: Contribution to journalArticle

Kovacs, SG, Reynolds, DG, Mckeown, P, Augereau, PG, Wasselle, JA, Ondrovic, LE & Aiba, M 1992, 'A magnetically actuated left ventricular assist device', ASAIO Journal, vol. 38, no. 1, pp. 38-46. https://doi.org/10.1097/00002480-199201000-00010
Kovacs SG, Reynolds DG, Mckeown P, Augereau PG, Wasselle JA, Ondrovic LE et al. A magnetically actuated left ventricular assist device. ASAIO Journal. 1992 Jan 1;38(1):38-46. https://doi.org/10.1097/00002480-199201000-00010
Kovacs, S. G. ; Reynolds, D. G. ; Mckeown, Peter ; Augereau, P. G. ; Wasselle, J. A. ; Ondrovic, L. E. ; Aiba, M. / A magnetically actuated left ventricular assist device. In: ASAIO Journal. 1992 ; Vol. 38, No. 1. pp. 38-46.
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