A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale A. Adeyemo, Matthew A. Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Guo Li, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun & 188 others Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris S. Carlson, John Carpten, Graham Casey, Wei Min Chen, Fang Chen, Yii Der I. Chen, Charleston W.K. Chiang, Gerhard A. Coetzee, Ellen Demerath, Sandra L. Deming-Halverson, Ryan W. Driver, Patricia Dubbert, Mary F. Feitosa, Ye Feng, Barry I. Freedman, Elizabeth M. Gillanders, Omri Gottesman, Xiuqing Guo, Talin Haritunians, Tamara Harris, Curtis C. Harris, Anselm J.M. Hennis, Dena G. Hernandez, Lorna H. McNeill, Timothy D. Howard, Barbara V. Howard, Virginia J. Howard, Karen Johnson, Sun J. Kang, Brendan J. Keating, Suzanne Kolb, Lewis H. Kuller, Abdullah Kutlar, Carl D. Langefeld, Guillaume Lettre, Kurt Lohman, Vaneet Lotay, Helen Lyon, Joann E. Manson, William Maixner, Yan A. Meng, Kristine R. Monroe, Imran Morhason-Bello, Adam B. Murphy, Josyf C. Mychaleckyj, Rajiv Nadukuru, Katherine L. Nathanson, Uma Nayak, Amidou N'Diaye, Barbara Nemesure, Suh Yuh Wu, M. Cristina Leske, Christine Neslund-Dudas, Marian Neuhouser, Sarah Nyante, Heather Ochs-Balcom, Adesola Ogunniyi, Temidayo O. Ogundiran, Oladosu Ojengbede, Olufunmilayo I. Olopade, Julie R. Palmer, Edward A. Ruiz-Narvaez, Nicholette D. Palmer, Michael F. Press, Evandine Rampersaud, Laura J. Rasmussen-Torvik, Jorge L. Rodriguez-Gil, Babatunde Salako, Eric E. Schadt, Ann G. Schwartz, Daniel A. Shriner, David Siscovick, Shad B. Smith, Sylvia Wassertheil-Smoller, Elizabeth K. Speliotes, Margaret R. Spitz, Lara Sucheston, Herman Taylor, Bamidele O. Tayo, Margaret A. Tucker, David J. Van Den Berg, Digna R.Velez Edwards, Zhaoming Wang, John K. Wiencke, Thomas W. Winkler, John S. Witte, Margaret Wrensch, Xifeng Wu, James J. Yang, Albert M. Levin, Taylor R. Young, Neil A. Zakai, Mary Cushman, Krista A. Zanetti, Jing Hua Zhao, Wei Zhao, Yonglan Zheng, Jie Zhou, Regina G. Ziegler, Joseph M. Zmuda, Jyotika K. Fernandes, Gary S. Gilkeson, Diane L. Kamen, Kelly J. Hunt, Ida J. Spruill, Christine B. Ambrosone, Stefan Ambs, Donna K. Arnett, Larry Atwood, Diane M. Becker, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Ingrid B. Borecki, Erwin P. Bottinger, Donald W. Bowden, Gregory Burke, Stephen J. Chanock, Richard S. Cooper, Jingzhong Ding, David Duggan, Michele K. Evans, Caroline Fox, W. Timothy Garvey, Jonathan P. Bradfield, Hakon Hakonarson, Struan F.A. Grant, Ann Hsing, Lisa Chu, Jennifer J. Hu, Dezheng Huo, Sue A. Ingles, Esther M. John, Joanne M. Jordan, Edmond K. Kabagambe, Sharon L.R. Kardia, Rick A. Kittles, Phyllis J. Goodman, Eric A. Klein, Laurence N. Kolonel, Loic Le Marchand, Simin Liu, Barbara McKnight, Robert C. Millikan, Thomas H. Mosley, Badri Padhukasahasram, L. Keoki Williams, Sanjay R. Patel, Ulrike Peters, Curtis A. Pettaway, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Charles N. Rotimi, Benjamin A. Rybicki, Michèle M. Sale, Pamela J. Schreiner, Lisa B. Signorello, Andrew B. Singleton, Janet L. Stanford, Sara S. Strom, Michael J. Thun, Mara Vitolins, Wei Zheng, Jason H. Moore, Scott M. Williams, Shamika Ketkar, Xiaofeng Zhu, Alan B. Zonderman, Charles Kooperberg, George J. Papanicolaou, Brian E. Henderson, Alex P. Reiner, Joel N. Hirschhorn, Ruth J.F. Loos, Kari E. North, Christopher A. Haiman

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

Original languageEnglish (US)
Pages (from-to)690-696
Number of pages7
JournalNature Genetics
Volume45
Issue number6
DOIs
StatePublished - Jun 1 2013

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Meta-Analysis
Body Mass Index
Genome-Wide Association Study
Population
Single Nucleotide Polymorphism
Genome

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., ... Haiman, C. A. (2013). A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nature Genetics, 45(6), 690-696. https://doi.org/10.1038/ng.2608

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. / Monda, Keri L.; Chen, Gary K.; Taylor, Kira C.; Palmer, Cameron; Edwards, Todd L.; Lange, Leslie A.; Ng, Maggie C.Y.; Adeyemo, Adebowale A.; Allison, Matthew A.; Bielak, Lawrence F.; Chen, Guanjie; Graff, Mariaelisa; Irvin, Marguerite R.; Rhie, Suhn K.; Li, Guo; Liu, Yongmei; Liu, Youfang; Lu, Yingchang; Nalls, Michael A.; Sun, Yan V.; Wojczynski, Mary K.; Yanek, Lisa R.; Aldrich, Melinda C.; Ademola, Adeyinka; Amos, Christopher I.; Bandera, Elisa V.; Bock, Cathryn H.; Britton, Angela; Broeckel, Ulrich; Cai, Quiyin; Caporaso, Neil E.; Carlson, Chris S.; Carpten, John; Casey, Graham; Chen, Wei Min; Chen, Fang; Chen, Yii Der I.; Chiang, Charleston W.K.; Coetzee, Gerhard A.; Demerath, Ellen; Deming-Halverson, Sandra L.; Driver, Ryan W.; Dubbert, Patricia; Feitosa, Mary F.; Feng, Ye; Freedman, Barry I.; Gillanders, Elizabeth M.; Gottesman, Omri; Guo, Xiuqing; Haritunians, Talin; Harris, Tamara; Harris, Curtis C.; Hennis, Anselm J.M.; Hernandez, Dena G.; McNeill, Lorna H.; Howard, Timothy D.; Howard, Barbara V.; Howard, Virginia J.; Johnson, Karen; Kang, Sun J.; Keating, Brendan J.; Kolb, Suzanne; Kuller, Lewis H.; Kutlar, Abdullah; Langefeld, Carl D.; Lettre, Guillaume; Lohman, Kurt; Lotay, Vaneet; Lyon, Helen; Manson, Joann E.; Maixner, William; Meng, Yan A.; Monroe, Kristine R.; Morhason-Bello, Imran; Murphy, Adam B.; Mychaleckyj, Josyf C.; Nadukuru, Rajiv; Nathanson, Katherine L.; Nayak, Uma; N'Diaye, Amidou; Nemesure, Barbara; Wu, Suh Yuh; Leske, M. Cristina; Neslund-Dudas, Christine; Neuhouser, Marian; Nyante, Sarah; Ochs-Balcom, Heather; Ogunniyi, Adesola; Ogundiran, Temidayo O.; Ojengbede, Oladosu; Olopade, Olufunmilayo I.; Palmer, Julie R.; Ruiz-Narvaez, Edward A.; Palmer, Nicholette D.; Press, Michael F.; Rampersaud, Evandine; Rasmussen-Torvik, Laura J.; Rodriguez-Gil, Jorge L.; Salako, Babatunde; Schadt, Eric E.; Schwartz, Ann G.; Shriner, Daniel A.; Siscovick, David; Smith, Shad B.; Wassertheil-Smoller, Sylvia; Speliotes, Elizabeth K.; Spitz, Margaret R.; Sucheston, Lara; Taylor, Herman; Tayo, Bamidele O.; Tucker, Margaret A.; Van Den Berg, David J.; Edwards, Digna R.Velez; Wang, Zhaoming; Wiencke, John K.; Winkler, Thomas W.; Witte, John S.; Wrensch, Margaret; Wu, Xifeng; Yang, James J.; Levin, Albert M.; Young, Taylor R.; Zakai, Neil A.; Cushman, Mary; Zanetti, Krista A.; Zhao, Jing Hua; Zhao, Wei; Zheng, Yonglan; Zhou, Jie; Ziegler, Regina G.; Zmuda, Joseph M.; Fernandes, Jyotika K.; Gilkeson, Gary S.; Kamen, Diane L.; Hunt, Kelly J.; Spruill, Ida J.; Ambrosone, Christine B.; Ambs, Stefan; Arnett, Donna K.; Atwood, Larry; Becker, Diane M.; Berndt, Sonja I.; Bernstein, Leslie; Blot, William J.; Borecki, Ingrid B.; Bottinger, Erwin P.; Bowden, Donald W.; Burke, Gregory; Chanock, Stephen J.; Cooper, Richard S.; Ding, Jingzhong; Duggan, David; Evans, Michele K.; Fox, Caroline; Garvey, W. Timothy; Bradfield, Jonathan P.; Hakonarson, Hakon; Grant, Struan F.A.; Hsing, Ann; Chu, Lisa; Hu, Jennifer J.; Huo, Dezheng; Ingles, Sue A.; John, Esther M.; Jordan, Joanne M.; Kabagambe, Edmond K.; Kardia, Sharon L.R.; Kittles, Rick A.; Goodman, Phyllis J.; Klein, Eric A.; Kolonel, Laurence N.; Le Marchand, Loic; Liu, Simin; McKnight, Barbara; Millikan, Robert C.; Mosley, Thomas H.; Padhukasahasram, Badri; Williams, L. Keoki; Patel, Sanjay R.; Peters, Ulrike; Pettaway, Curtis A.; Peyser, Patricia A.; Psaty, Bruce M.; Redline, Susan; Rotimi, Charles N.; Rybicki, Benjamin A.; Sale, Michèle M.; Schreiner, Pamela J.; Signorello, Lisa B.; Singleton, Andrew B.; Stanford, Janet L.; Strom, Sara S.; Thun, Michael J.; Vitolins, Mara; Zheng, Wei; Moore, Jason H.; Williams, Scott M.; Ketkar, Shamika; Zhu, Xiaofeng; Zonderman, Alan B.; Kooperberg, Charles; Papanicolaou, George J.; Henderson, Brian E.; Reiner, Alex P.; Hirschhorn, Joel N.; Loos, Ruth J.F.; North, Kari E.; Haiman, Christopher A.

In: Nature Genetics, Vol. 45, No. 6, 01.06.2013, p. 690-696.

Research output: Contribution to journalArticle

Monda, KL, Chen, GK, Taylor, KC, Palmer, C, Edwards, TL, Lange, LA, Ng, MCY, Adeyemo, AA, Allison, MA, Bielak, LF, Chen, G, Graff, M, Irvin, MR, Rhie, SK, Li, G, Liu, Y, Liu, Y, Lu, Y, Nalls, MA, Sun, YV, Wojczynski, MK, Yanek, LR, Aldrich, MC, Ademola, A, Amos, CI, Bandera, EV, Bock, CH, Britton, A, Broeckel, U, Cai, Q, Caporaso, NE, Carlson, CS, Carpten, J, Casey, G, Chen, WM, Chen, F, Chen, YDI, Chiang, CWK, Coetzee, GA, Demerath, E, Deming-Halverson, SL, Driver, RW, Dubbert, P, Feitosa, MF, Feng, Y, Freedman, BI, Gillanders, EM, Gottesman, O, Guo, X, Haritunians, T, Harris, T, Harris, CC, Hennis, AJM, Hernandez, DG, McNeill, LH, Howard, TD, Howard, BV, Howard, VJ, Johnson, K, Kang, SJ, Keating, BJ, Kolb, S, Kuller, LH, Kutlar, A, Langefeld, CD, Lettre, G, Lohman, K, Lotay, V, Lyon, H, Manson, JE, Maixner, W, Meng, YA, Monroe, KR, Morhason-Bello, I, Murphy, AB, Mychaleckyj, JC, Nadukuru, R, Nathanson, KL, Nayak, U, N'Diaye, A, Nemesure, B, Wu, SY, Leske, MC, Neslund-Dudas, C, Neuhouser, M, Nyante, S, Ochs-Balcom, H, Ogunniyi, A, Ogundiran, TO, Ojengbede, O, Olopade, OI, Palmer, JR, Ruiz-Narvaez, EA, Palmer, ND, Press, MF, Rampersaud, E, Rasmussen-Torvik, LJ, Rodriguez-Gil, JL, Salako, B, Schadt, EE, Schwartz, AG, Shriner, DA, Siscovick, D, Smith, SB, Wassertheil-Smoller, S, Speliotes, EK, Spitz, MR, Sucheston, L, Taylor, H, Tayo, BO, Tucker, MA, Van Den Berg, DJ, Edwards, DRV, Wang, Z, Wiencke, JK, Winkler, TW, Witte, JS, Wrensch, M, Wu, X, Yang, JJ, Levin, AM, Young, TR, Zakai, NA, Cushman, M, Zanetti, KA, Zhao, JH, Zhao, W, Zheng, Y, Zhou, J, Ziegler, RG, Zmuda, JM, Fernandes, JK, Gilkeson, GS, Kamen, DL, Hunt, KJ, Spruill, IJ, Ambrosone, CB, Ambs, S, Arnett, DK, Atwood, L, Becker, DM, Berndt, SI, Bernstein, L, Blot, WJ, Borecki, IB, Bottinger, EP, Bowden, DW, Burke, G, Chanock, SJ, Cooper, RS, Ding, J, Duggan, D, Evans, MK, Fox, C, Garvey, WT, Bradfield, JP, Hakonarson, H, Grant, SFA, Hsing, A, Chu, L, Hu, JJ, Huo, D, Ingles, SA, John, EM, Jordan, JM, Kabagambe, EK, Kardia, SLR, Kittles, RA, Goodman, PJ, Klein, EA, Kolonel, LN, Le Marchand, L, Liu, S, McKnight, B, Millikan, RC, Mosley, TH, Padhukasahasram, B, Williams, LK, Patel, SR, Peters, U, Pettaway, CA, Peyser, PA, Psaty, BM, Redline, S, Rotimi, CN, Rybicki, BA, Sale, MM, Schreiner, PJ, Signorello, LB, Singleton, AB, Stanford, JL, Strom, SS, Thun, MJ, Vitolins, M, Zheng, W, Moore, JH, Williams, SM, Ketkar, S, Zhu, X, Zonderman, AB, Kooperberg, C, Papanicolaou, GJ, Henderson, BE, Reiner, AP, Hirschhorn, JN, Loos, RJF, North, KE & Haiman, CA 2013, 'A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry', Nature Genetics, vol. 45, no. 6, pp. 690-696. https://doi.org/10.1038/ng.2608
Monda, Keri L. ; Chen, Gary K. ; Taylor, Kira C. ; Palmer, Cameron ; Edwards, Todd L. ; Lange, Leslie A. ; Ng, Maggie C.Y. ; Adeyemo, Adebowale A. ; Allison, Matthew A. ; Bielak, Lawrence F. ; Chen, Guanjie ; Graff, Mariaelisa ; Irvin, Marguerite R. ; Rhie, Suhn K. ; Li, Guo ; Liu, Yongmei ; Liu, Youfang ; Lu, Yingchang ; Nalls, Michael A. ; Sun, Yan V. ; Wojczynski, Mary K. ; Yanek, Lisa R. ; Aldrich, Melinda C. ; Ademola, Adeyinka ; Amos, Christopher I. ; Bandera, Elisa V. ; Bock, Cathryn H. ; Britton, Angela ; Broeckel, Ulrich ; Cai, Quiyin ; Caporaso, Neil E. ; Carlson, Chris S. ; Carpten, John ; Casey, Graham ; Chen, Wei Min ; Chen, Fang ; Chen, Yii Der I. ; Chiang, Charleston W.K. ; Coetzee, Gerhard A. ; Demerath, Ellen ; Deming-Halverson, Sandra L. ; Driver, Ryan W. ; Dubbert, Patricia ; Feitosa, Mary F. ; Feng, Ye ; Freedman, Barry I. ; Gillanders, Elizabeth M. ; Gottesman, Omri ; Guo, Xiuqing ; Haritunians, Talin ; Harris, Tamara ; Harris, Curtis C. ; Hennis, Anselm J.M. ; Hernandez, Dena G. ; McNeill, Lorna H. ; Howard, Timothy D. ; Howard, Barbara V. ; Howard, Virginia J. ; Johnson, Karen ; Kang, Sun J. ; Keating, Brendan J. ; Kolb, Suzanne ; Kuller, Lewis H. ; Kutlar, Abdullah ; Langefeld, Carl D. ; Lettre, Guillaume ; Lohman, Kurt ; Lotay, Vaneet ; Lyon, Helen ; Manson, Joann E. ; Maixner, William ; Meng, Yan A. ; Monroe, Kristine R. ; Morhason-Bello, Imran ; Murphy, Adam B. ; Mychaleckyj, Josyf C. ; Nadukuru, Rajiv ; Nathanson, Katherine L. ; Nayak, Uma ; N'Diaye, Amidou ; Nemesure, Barbara ; Wu, Suh Yuh ; Leske, M. Cristina ; Neslund-Dudas, Christine ; Neuhouser, Marian ; Nyante, Sarah ; Ochs-Balcom, Heather ; Ogunniyi, Adesola ; Ogundiran, Temidayo O. ; Ojengbede, Oladosu ; Olopade, Olufunmilayo I. ; Palmer, Julie R. ; Ruiz-Narvaez, Edward A. ; Palmer, Nicholette D. ; Press, Michael F. ; Rampersaud, Evandine ; Rasmussen-Torvik, Laura J. ; Rodriguez-Gil, Jorge L. ; Salako, Babatunde ; Schadt, Eric E. ; Schwartz, Ann G. ; Shriner, Daniel A. ; Siscovick, David ; Smith, Shad B. ; Wassertheil-Smoller, Sylvia ; Speliotes, Elizabeth K. ; Spitz, Margaret R. ; Sucheston, Lara ; Taylor, Herman ; Tayo, Bamidele O. ; Tucker, Margaret A. ; Van Den Berg, David J. ; Edwards, Digna R.Velez ; Wang, Zhaoming ; Wiencke, John K. ; Winkler, Thomas W. ; Witte, John S. ; Wrensch, Margaret ; Wu, Xifeng ; Yang, James J. ; Levin, Albert M. ; Young, Taylor R. ; Zakai, Neil A. ; Cushman, Mary ; Zanetti, Krista A. ; Zhao, Jing Hua ; Zhao, Wei ; Zheng, Yonglan ; Zhou, Jie ; Ziegler, Regina G. ; Zmuda, Joseph M. ; Fernandes, Jyotika K. ; Gilkeson, Gary S. ; Kamen, Diane L. ; Hunt, Kelly J. ; Spruill, Ida J. ; Ambrosone, Christine B. ; Ambs, Stefan ; Arnett, Donna K. ; Atwood, Larry ; Becker, Diane M. ; Berndt, Sonja I. ; Bernstein, Leslie ; Blot, William J. ; Borecki, Ingrid B. ; Bottinger, Erwin P. ; Bowden, Donald W. ; Burke, Gregory ; Chanock, Stephen J. ; Cooper, Richard S. ; Ding, Jingzhong ; Duggan, David ; Evans, Michele K. ; Fox, Caroline ; Garvey, W. Timothy ; Bradfield, Jonathan P. ; Hakonarson, Hakon ; Grant, Struan F.A. ; Hsing, Ann ; Chu, Lisa ; Hu, Jennifer J. ; Huo, Dezheng ; Ingles, Sue A. ; John, Esther M. ; Jordan, Joanne M. ; Kabagambe, Edmond K. ; Kardia, Sharon L.R. ; Kittles, Rick A. ; Goodman, Phyllis J. ; Klein, Eric A. ; Kolonel, Laurence N. ; Le Marchand, Loic ; Liu, Simin ; McKnight, Barbara ; Millikan, Robert C. ; Mosley, Thomas H. ; Padhukasahasram, Badri ; Williams, L. Keoki ; Patel, Sanjay R. ; Peters, Ulrike ; Pettaway, Curtis A. ; Peyser, Patricia A. ; Psaty, Bruce M. ; Redline, Susan ; Rotimi, Charles N. ; Rybicki, Benjamin A. ; Sale, Michèle M. ; Schreiner, Pamela J. ; Signorello, Lisa B. ; Singleton, Andrew B. ; Stanford, Janet L. ; Strom, Sara S. ; Thun, Michael J. ; Vitolins, Mara ; Zheng, Wei ; Moore, Jason H. ; Williams, Scott M. ; Ketkar, Shamika ; Zhu, Xiaofeng ; Zonderman, Alan B. ; Kooperberg, Charles ; Papanicolaou, George J. ; Henderson, Brian E. ; Reiner, Alex P. ; Hirschhorn, Joel N. ; Loos, Ruth J.F. ; North, Kari E. ; Haiman, Christopher A. / A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. In: Nature Genetics. 2013 ; Vol. 45, No. 6. pp. 690-696.
@article{90b13f3d587b43779f89655ef793235c,
title = "A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry",
abstract = "Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.",
author = "Monda, {Keri L.} and Chen, {Gary K.} and Taylor, {Kira C.} and Cameron Palmer and Edwards, {Todd L.} and Lange, {Leslie A.} and Ng, {Maggie C.Y.} and Adeyemo, {Adebowale A.} and Allison, {Matthew A.} and Bielak, {Lawrence F.} and Guanjie Chen and Mariaelisa Graff and Irvin, {Marguerite R.} and Rhie, {Suhn K.} and Guo Li and Yongmei Liu and Youfang Liu and Yingchang Lu and Nalls, {Michael A.} and Sun, {Yan V.} and Wojczynski, {Mary K.} and Yanek, {Lisa R.} and Aldrich, {Melinda C.} and Adeyinka Ademola and Amos, {Christopher I.} and Bandera, {Elisa V.} and Bock, {Cathryn H.} and Angela Britton and Ulrich Broeckel and Quiyin Cai and Caporaso, {Neil E.} and Carlson, {Chris S.} and John Carpten and Graham Casey and Chen, {Wei Min} and Fang Chen and Chen, {Yii Der I.} and Chiang, {Charleston W.K.} and Coetzee, {Gerhard A.} and Ellen Demerath and Deming-Halverson, {Sandra L.} and Driver, {Ryan W.} and Patricia Dubbert and Feitosa, {Mary F.} and Ye Feng and Freedman, {Barry I.} and Gillanders, {Elizabeth M.} and Omri Gottesman and Xiuqing Guo and Talin Haritunians and Tamara Harris and Harris, {Curtis C.} and Hennis, {Anselm J.M.} and Hernandez, {Dena G.} and McNeill, {Lorna H.} and Howard, {Timothy D.} and Howard, {Barbara V.} and Howard, {Virginia J.} and Karen Johnson and Kang, {Sun J.} and Keating, {Brendan J.} and Suzanne Kolb and Kuller, {Lewis H.} and Abdullah Kutlar and Langefeld, {Carl D.} and Guillaume Lettre and Kurt Lohman and Vaneet Lotay and Helen Lyon and Manson, {Joann E.} and William Maixner and Meng, {Yan A.} and Monroe, {Kristine R.} and Imran Morhason-Bello and Murphy, {Adam B.} and Mychaleckyj, {Josyf C.} and Rajiv Nadukuru and Nathanson, {Katherine L.} and Uma Nayak and Amidou N'Diaye and Barbara Nemesure and Wu, {Suh Yuh} and Leske, {M. Cristina} and Christine Neslund-Dudas and Marian Neuhouser and Sarah Nyante and Heather Ochs-Balcom and Adesola Ogunniyi and Ogundiran, {Temidayo O.} and Oladosu Ojengbede and Olopade, {Olufunmilayo I.} and Palmer, {Julie R.} and Ruiz-Narvaez, {Edward A.} and Palmer, {Nicholette D.} and Press, {Michael F.} and Evandine Rampersaud and Rasmussen-Torvik, {Laura J.} and Rodriguez-Gil, {Jorge L.} and Babatunde Salako and Schadt, {Eric E.} and Schwartz, {Ann G.} and Shriner, {Daniel A.} and David Siscovick and Smith, {Shad B.} and Sylvia Wassertheil-Smoller and Speliotes, {Elizabeth K.} and Spitz, {Margaret R.} and Lara Sucheston and Herman Taylor and Tayo, {Bamidele O.} and Tucker, {Margaret A.} and {Van Den Berg}, {David J.} and Edwards, {Digna R.Velez} and Zhaoming Wang and Wiencke, {John K.} and Winkler, {Thomas W.} and Witte, {John S.} and Margaret Wrensch and Xifeng Wu and Yang, {James J.} and Levin, {Albert M.} and Young, {Taylor R.} and Zakai, {Neil A.} and Mary Cushman and Zanetti, {Krista A.} and Zhao, {Jing Hua} and Wei Zhao and Yonglan Zheng and Jie Zhou and Ziegler, {Regina G.} and Zmuda, {Joseph M.} and Fernandes, {Jyotika K.} and Gilkeson, {Gary S.} and Kamen, {Diane L.} and Hunt, {Kelly J.} and Spruill, {Ida J.} and Ambrosone, {Christine B.} and Stefan Ambs and Arnett, {Donna K.} and Larry Atwood and Becker, {Diane M.} and Berndt, {Sonja I.} and Leslie Bernstein and Blot, {William J.} and Borecki, {Ingrid B.} and Bottinger, {Erwin P.} and Bowden, {Donald W.} and Gregory Burke and Chanock, {Stephen J.} and Cooper, {Richard S.} and Jingzhong Ding and David Duggan and Evans, {Michele K.} and Caroline Fox and Garvey, {W. Timothy} and Bradfield, {Jonathan P.} and Hakon Hakonarson and Grant, {Struan F.A.} and Ann Hsing and Lisa Chu and Hu, {Jennifer J.} and Dezheng Huo and Ingles, {Sue A.} and John, {Esther M.} and Jordan, {Joanne M.} and Kabagambe, {Edmond K.} and Kardia, {Sharon L.R.} and Kittles, {Rick A.} and Goodman, {Phyllis J.} and Klein, {Eric A.} and Kolonel, {Laurence N.} and {Le Marchand}, Loic and Simin Liu and Barbara McKnight and Millikan, {Robert C.} and Mosley, {Thomas H.} and Badri Padhukasahasram and Williams, {L. Keoki} and Patel, {Sanjay R.} and Ulrike Peters and Pettaway, {Curtis A.} and Peyser, {Patricia A.} and Psaty, {Bruce M.} and Susan Redline and Rotimi, {Charles N.} and Rybicki, {Benjamin A.} and Sale, {Mich{\`e}le M.} and Schreiner, {Pamela J.} and Signorello, {Lisa B.} and Singleton, {Andrew B.} and Stanford, {Janet L.} and Strom, {Sara S.} and Thun, {Michael J.} and Mara Vitolins and Wei Zheng and Moore, {Jason H.} and Williams, {Scott M.} and Shamika Ketkar and Xiaofeng Zhu and Zonderman, {Alan B.} and Charles Kooperberg and Papanicolaou, {George J.} and Henderson, {Brian E.} and Reiner, {Alex P.} and Hirschhorn, {Joel N.} and Loos, {Ruth J.F.} and North, {Kari E.} and Haiman, {Christopher A.}",
year = "2013",
month = "6",
day = "1",
doi = "10.1038/ng.2608",
language = "English (US)",
volume = "45",
pages = "690--696",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

AU - Monda, Keri L.

AU - Chen, Gary K.

AU - Taylor, Kira C.

AU - Palmer, Cameron

AU - Edwards, Todd L.

AU - Lange, Leslie A.

AU - Ng, Maggie C.Y.

AU - Adeyemo, Adebowale A.

AU - Allison, Matthew A.

AU - Bielak, Lawrence F.

AU - Chen, Guanjie

AU - Graff, Mariaelisa

AU - Irvin, Marguerite R.

AU - Rhie, Suhn K.

AU - Li, Guo

AU - Liu, Yongmei

AU - Liu, Youfang

AU - Lu, Yingchang

AU - Nalls, Michael A.

AU - Sun, Yan V.

AU - Wojczynski, Mary K.

AU - Yanek, Lisa R.

AU - Aldrich, Melinda C.

AU - Ademola, Adeyinka

AU - Amos, Christopher I.

AU - Bandera, Elisa V.

AU - Bock, Cathryn H.

AU - Britton, Angela

AU - Broeckel, Ulrich

AU - Cai, Quiyin

AU - Caporaso, Neil E.

AU - Carlson, Chris S.

AU - Carpten, John

AU - Casey, Graham

AU - Chen, Wei Min

AU - Chen, Fang

AU - Chen, Yii Der I.

AU - Chiang, Charleston W.K.

AU - Coetzee, Gerhard A.

AU - Demerath, Ellen

AU - Deming-Halverson, Sandra L.

AU - Driver, Ryan W.

AU - Dubbert, Patricia

AU - Feitosa, Mary F.

AU - Feng, Ye

AU - Freedman, Barry I.

AU - Gillanders, Elizabeth M.

AU - Gottesman, Omri

AU - Guo, Xiuqing

AU - Haritunians, Talin

AU - Harris, Tamara

AU - Harris, Curtis C.

AU - Hennis, Anselm J.M.

AU - Hernandez, Dena G.

AU - McNeill, Lorna H.

AU - Howard, Timothy D.

AU - Howard, Barbara V.

AU - Howard, Virginia J.

AU - Johnson, Karen

AU - Kang, Sun J.

AU - Keating, Brendan J.

AU - Kolb, Suzanne

AU - Kuller, Lewis H.

AU - Kutlar, Abdullah

AU - Langefeld, Carl D.

AU - Lettre, Guillaume

AU - Lohman, Kurt

AU - Lotay, Vaneet

AU - Lyon, Helen

AU - Manson, Joann E.

AU - Maixner, William

AU - Meng, Yan A.

AU - Monroe, Kristine R.

AU - Morhason-Bello, Imran

AU - Murphy, Adam B.

AU - Mychaleckyj, Josyf C.

AU - Nadukuru, Rajiv

AU - Nathanson, Katherine L.

AU - Nayak, Uma

AU - N'Diaye, Amidou

AU - Nemesure, Barbara

AU - Wu, Suh Yuh

AU - Leske, M. Cristina

AU - Neslund-Dudas, Christine

AU - Neuhouser, Marian

AU - Nyante, Sarah

AU - Ochs-Balcom, Heather

AU - Ogunniyi, Adesola

AU - Ogundiran, Temidayo O.

AU - Ojengbede, Oladosu

AU - Olopade, Olufunmilayo I.

AU - Palmer, Julie R.

AU - Ruiz-Narvaez, Edward A.

AU - Palmer, Nicholette D.

AU - Press, Michael F.

AU - Rampersaud, Evandine

AU - Rasmussen-Torvik, Laura J.

AU - Rodriguez-Gil, Jorge L.

AU - Salako, Babatunde

AU - Schadt, Eric E.

AU - Schwartz, Ann G.

AU - Shriner, Daniel A.

AU - Siscovick, David

AU - Smith, Shad B.

AU - Wassertheil-Smoller, Sylvia

AU - Speliotes, Elizabeth K.

AU - Spitz, Margaret R.

AU - Sucheston, Lara

AU - Taylor, Herman

AU - Tayo, Bamidele O.

AU - Tucker, Margaret A.

AU - Van Den Berg, David J.

AU - Edwards, Digna R.Velez

AU - Wang, Zhaoming

AU - Wiencke, John K.

AU - Winkler, Thomas W.

AU - Witte, John S.

AU - Wrensch, Margaret

AU - Wu, Xifeng

AU - Yang, James J.

AU - Levin, Albert M.

AU - Young, Taylor R.

AU - Zakai, Neil A.

AU - Cushman, Mary

AU - Zanetti, Krista A.

AU - Zhao, Jing Hua

AU - Zhao, Wei

AU - Zheng, Yonglan

AU - Zhou, Jie

AU - Ziegler, Regina G.

AU - Zmuda, Joseph M.

AU - Fernandes, Jyotika K.

AU - Gilkeson, Gary S.

AU - Kamen, Diane L.

AU - Hunt, Kelly J.

AU - Spruill, Ida J.

AU - Ambrosone, Christine B.

AU - Ambs, Stefan

AU - Arnett, Donna K.

AU - Atwood, Larry

AU - Becker, Diane M.

AU - Berndt, Sonja I.

AU - Bernstein, Leslie

AU - Blot, William J.

AU - Borecki, Ingrid B.

AU - Bottinger, Erwin P.

AU - Bowden, Donald W.

AU - Burke, Gregory

AU - Chanock, Stephen J.

AU - Cooper, Richard S.

AU - Ding, Jingzhong

AU - Duggan, David

AU - Evans, Michele K.

AU - Fox, Caroline

AU - Garvey, W. Timothy

AU - Bradfield, Jonathan P.

AU - Hakonarson, Hakon

AU - Grant, Struan F.A.

AU - Hsing, Ann

AU - Chu, Lisa

AU - Hu, Jennifer J.

AU - Huo, Dezheng

AU - Ingles, Sue A.

AU - John, Esther M.

AU - Jordan, Joanne M.

AU - Kabagambe, Edmond K.

AU - Kardia, Sharon L.R.

AU - Kittles, Rick A.

AU - Goodman, Phyllis J.

AU - Klein, Eric A.

AU - Kolonel, Laurence N.

AU - Le Marchand, Loic

AU - Liu, Simin

AU - McKnight, Barbara

AU - Millikan, Robert C.

AU - Mosley, Thomas H.

AU - Padhukasahasram, Badri

AU - Williams, L. Keoki

AU - Patel, Sanjay R.

AU - Peters, Ulrike

AU - Pettaway, Curtis A.

AU - Peyser, Patricia A.

AU - Psaty, Bruce M.

AU - Redline, Susan

AU - Rotimi, Charles N.

AU - Rybicki, Benjamin A.

AU - Sale, Michèle M.

AU - Schreiner, Pamela J.

AU - Signorello, Lisa B.

AU - Singleton, Andrew B.

AU - Stanford, Janet L.

AU - Strom, Sara S.

AU - Thun, Michael J.

AU - Vitolins, Mara

AU - Zheng, Wei

AU - Moore, Jason H.

AU - Williams, Scott M.

AU - Ketkar, Shamika

AU - Zhu, Xiaofeng

AU - Zonderman, Alan B.

AU - Kooperberg, Charles

AU - Papanicolaou, George J.

AU - Henderson, Brian E.

AU - Reiner, Alex P.

AU - Hirschhorn, Joel N.

AU - Loos, Ruth J.F.

AU - North, Kari E.

AU - Haiman, Christopher A.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

AB - Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

UR - http://www.scopus.com/inward/record.url?scp=84878720938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878720938&partnerID=8YFLogxK

U2 - 10.1038/ng.2608

DO - 10.1038/ng.2608

M3 - Article

VL - 45

SP - 690

EP - 696

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -