A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation

Ravindra Arya, Abbas Babajani-Feremi, Anna W. Byars, Jennifer Vannest, Hansel M. Greiner, James Wheless, Francesco T. Mangano, Katherine D. Holland

Research output: Contribution to journalArticle

Abstract

Objective: We studied spatiotemporal dynamics of electrocorticographic (ECoG) high-gamma modulation (HGM) during visual naming. Methods: In 8 patients, aged 4–19 years, with left hemisphere subdural electrodes, propagation of ECoG HGM during overt visual naming was mapped with trial-averaged time-frequency analysis. Group-level synthesis was performed by transforming all electrodes to a standard space and assigning cortical parcels based on a reference atlas. Results: After image display following cortical parcels were activated: inferior occipital, caudal angular, fusiform, and middle temporal gyri, and superior temporal sulcus [0–400 ms]; rostral pars triangularis (A45r), inferior frontal sulcus, caudal dorsolateral premotor cortex (A6cdl) [300–600 ms]; caudal ventrolateral premotor cortex (A6cvl), caudal pars triangularis (A45c), pars opercularis (A44) [400–800 ms]; primary sensorimotor cortex [600–1400 ms], with most prominent HGM in glossolaryngeal region (A4tl). Lastly, auditory cortex (A41/A42) and superior temporal gyrus (A22) were activated [900 ms–1.4 s]. After 1.5 s, HGM decreased globally, except in ventrolateral premotor cortex. Conclusions: During visual naming, ECoG HGM shows a sequential but overlapping spatiotemporal course through cortical regions. We provide neurophysiologic validation for a model of visual naming incorporating both modular and distributed cortical processing. This may explain cognitive deficits seen in some patients after surgery involving HGM naming sites outside perisylvian language cortex.

Original languageEnglish (US)
Article number106455
JournalEpilepsy and Behavior
Volume99
DOIs
StatePublished - Oct 1 2019

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Motor Cortex
Temporal Lobe
Electrodes
Auditory Cortex
Atlases
Prefrontal Cortex
Language
Broca Area

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation. / Arya, Ravindra; Babajani-Feremi, Abbas; Byars, Anna W.; Vannest, Jennifer; Greiner, Hansel M.; Wheless, James; Mangano, Francesco T.; Holland, Katherine D.

In: Epilepsy and Behavior, Vol. 99, 106455, 01.10.2019.

Research output: Contribution to journalArticle

Arya, Ravindra ; Babajani-Feremi, Abbas ; Byars, Anna W. ; Vannest, Jennifer ; Greiner, Hansel M. ; Wheless, James ; Mangano, Francesco T. ; Holland, Katherine D. / A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation. In: Epilepsy and Behavior. 2019 ; Vol. 99.
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abstract = "Objective: We studied spatiotemporal dynamics of electrocorticographic (ECoG) high-gamma modulation (HGM) during visual naming. Methods: In 8 patients, aged 4–19 years, with left hemisphere subdural electrodes, propagation of ECoG HGM during overt visual naming was mapped with trial-averaged time-frequency analysis. Group-level synthesis was performed by transforming all electrodes to a standard space and assigning cortical parcels based on a reference atlas. Results: After image display following cortical parcels were activated: inferior occipital, caudal angular, fusiform, and middle temporal gyri, and superior temporal sulcus [0–400 ms]; rostral pars triangularis (A45r), inferior frontal sulcus, caudal dorsolateral premotor cortex (A6cdl) [300–600 ms]; caudal ventrolateral premotor cortex (A6cvl), caudal pars triangularis (A45c), pars opercularis (A44) [400–800 ms]; primary sensorimotor cortex [600–1400 ms], with most prominent HGM in glossolaryngeal region (A4tl). Lastly, auditory cortex (A41/A42) and superior temporal gyrus (A22) were activated [900 ms–1.4 s]. After 1.5 s, HGM decreased globally, except in ventrolateral premotor cortex. Conclusions: During visual naming, ECoG HGM shows a sequential but overlapping spatiotemporal course through cortical regions. We provide neurophysiologic validation for a model of visual naming incorporating both modular and distributed cortical processing. This may explain cognitive deficits seen in some patients after surgery involving HGM naming sites outside perisylvian language cortex.",
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