A molecular basis for nonsecretory myeloma

Daniel Coriu, Kristal Weaver, Maria Schell, Manfred Eulitz, Charles L. Murphy, Deborah T. Weiss, Alan Solomon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The biosynthesis of aberrant immunoglobulin polypeptides by monoclonal plasma cells has been implicated in the pathogenesis of nonsecretory myeloma. Our studies of a patient with this disorder indeed have demonstrated the presence of abnormal K light chains that resulted from a frameshift mutation in nucleotides encoding the constant region of the molecule. As a consequence of a 2-base deletion in codon 187 and loss of the normal stop codon, this portion of the K chain was composed of 128 amino acids (rather than the expected 106), with a completely anomalous sequence after position 187 that included absence of the cysteines required for intrachain and interchain disulfide bonds. The unusual primary structure of this component was confirmed by mass spectrometric and amino acid sequence analyses of cytoplasmic protein extracts. Our studies provide the first evidence that human nonsecretory myeloma may result from an alteration in the light-chain constant region.

Original languageEnglish (US)
Pages (from-to)829-831
Number of pages3
JournalBlood
Volume104
Issue number3
DOIs
StatePublished - Aug 1 2004

Fingerprint

Light
Amino Acids
Frameshift Mutation
Terminator Codon
Biosynthesis
Protein Sequence Analysis
Plasma Cells
Codon
Disulfides
Cysteine
Immunoglobulins
Nucleotides
Plasmas
Peptides
Molecules
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Coriu, D., Weaver, K., Schell, M., Eulitz, M., Murphy, C. L., Weiss, D. T., & Solomon, A. (2004). A molecular basis for nonsecretory myeloma. Blood, 104(3), 829-831. https://doi.org/10.1182/blood-2004-02-0477

A molecular basis for nonsecretory myeloma. / Coriu, Daniel; Weaver, Kristal; Schell, Maria; Eulitz, Manfred; Murphy, Charles L.; Weiss, Deborah T.; Solomon, Alan.

In: Blood, Vol. 104, No. 3, 01.08.2004, p. 829-831.

Research output: Contribution to journalArticle

Coriu, D, Weaver, K, Schell, M, Eulitz, M, Murphy, CL, Weiss, DT & Solomon, A 2004, 'A molecular basis for nonsecretory myeloma', Blood, vol. 104, no. 3, pp. 829-831. https://doi.org/10.1182/blood-2004-02-0477
Coriu D, Weaver K, Schell M, Eulitz M, Murphy CL, Weiss DT et al. A molecular basis for nonsecretory myeloma. Blood. 2004 Aug 1;104(3):829-831. https://doi.org/10.1182/blood-2004-02-0477
Coriu, Daniel ; Weaver, Kristal ; Schell, Maria ; Eulitz, Manfred ; Murphy, Charles L. ; Weiss, Deborah T. ; Solomon, Alan. / A molecular basis for nonsecretory myeloma. In: Blood. 2004 ; Vol. 104, No. 3. pp. 829-831.
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