A "monoclonal" type, low molecular weight protein related to γM-macroglobulins

Alan Solomon, Henry G. Kunkel

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A unique "monoclonal" gamma globulin was detected in the serum of a patient with malignant disease of the plasma cell-lymphatic system. This protein had antigenic determinants common to 19S γM-globulin (macroglobulin) but there were marked physicochemical differences. The clinical and pathologic findings in this patient differed from those usually found in patients with multiple myeloma or Waldenström's macroglobulinemia. Evidence obtained from density gradient and gel filtration studies of whole serum indicated that the γM antigenic determinants were located primarily on molecules smaller in size than 19S-globulin. The anomalous gamma globulin, isolated from serum, had a sedimentation coefficient (s20, w) of 6.5S, consisted of μ-type heavy chains and λ-type light chains and differed slightly from the monomeric subunits of a reduced alkylated 19S γM-globulin. This protein may be related to low molecular weight γM antibodies previously described in a normal serum and in several disease states.

Original languageEnglish (US)
Pages (from-to)958-967
Number of pages10
JournalThe American journal of medicine
Volume42
Issue number6
StatePublished - Jun 1 1967
Externally publishedYes

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Macroglobulins
Globulins
Molecular Weight
gamma-Globulins
Serum
Epitopes
Proteins
Waldenstrom Macroglobulinemia
Lymphatic System
Plasma Cells
Multiple Myeloma
Gel Chromatography
Light
Antibodies

All Science Journal Classification (ASJC) codes

  • Nursing(all)

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A "monoclonal" type, low molecular weight protein related to γM-macroglobulins. / Solomon, Alan; Kunkel, Henry G.

In: The American journal of medicine, Vol. 42, No. 6, 01.06.1967, p. 958-967.

Research output: Contribution to journalArticle

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