A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-tc, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds

Gary F. Purdue, John L. Hunt, Joseph M. Still, Edward J. Law, David N. Herndon, I. William Goldfarb, William R. Schiller, John F. Hansbrough, William Hickerson, Harvey N. Himel, G. Patrick Kealey, John Twomey, Anne E. Missavage, Lynn D. Solem, Michelle Davis, Mark Totoritis, Gary D. Gentzkow

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

This multicenter study compared die use of a biosyntlietic human skin substitute with frozen human cadaver allograft for die temporary closure of excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a synthetic material onto which human neonatal fibroblasts are cultured. Burn wounds in 66 patients with a mean age of 36 years and a mean burn size of 44% total body surface area (28% total body surface area full-thickness) were surgically excised. Two comparable sites, each approximately 1% total body surface area in size, were randomized to receive either DG-TC or allograft. Bodi sites were then treated in the same manner. When clinically indicated (>5 days after application) both skin replacements were removed, and the wound beds were evaluated and prepared for grafting. DG-TC was equivalent or superior to allograft with regard to autograft take at post autograft day 14. DG-TC was also easier to remove, had no epidermal slough, and resulted in less bleeding than did allograft while maintaining an adequate wound bed. Overall satisfaction was better widi DG-TC.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1997

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Cadaver
Multicenter Studies
Allografts
Body Surface Area
Clinical Trials
Skin
Autografts
Wounds and Injuries
Artificial Skin
Fibroblasts
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

Cite this

A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-tc, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. / Purdue, Gary F.; Hunt, John L.; Still, Joseph M.; Law, Edward J.; Herndon, David N.; William Goldfarb, I.; Schiller, William R.; Hansbrough, John F.; Hickerson, William; Himel, Harvey N.; Patrick Kealey, G.; Twomey, John; Missavage, Anne E.; Solem, Lynn D.; Davis, Michelle; Totoritis, Mark; Gentzkow, Gary D.

In: Journal of Burn Care and Rehabilitation, Vol. 18, No. 1, 01.01.1997, p. 52-57.

Research output: Contribution to journalArticle

Purdue, GF, Hunt, JL, Still, JM, Law, EJ, Herndon, DN, William Goldfarb, I, Schiller, WR, Hansbrough, JF, Hickerson, W, Himel, HN, Patrick Kealey, G, Twomey, J, Missavage, AE, Solem, LD, Davis, M, Totoritis, M & Gentzkow, GD 1997, 'A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-tc, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds', Journal of Burn Care and Rehabilitation, vol. 18, no. 1, pp. 52-57. https://doi.org/10.1097/00004630-199701000-00009
Purdue, Gary F. ; Hunt, John L. ; Still, Joseph M. ; Law, Edward J. ; Herndon, David N. ; William Goldfarb, I. ; Schiller, William R. ; Hansbrough, John F. ; Hickerson, William ; Himel, Harvey N. ; Patrick Kealey, G. ; Twomey, John ; Missavage, Anne E. ; Solem, Lynn D. ; Davis, Michelle ; Totoritis, Mark ; Gentzkow, Gary D. / A multicenter clinical trial of a biosynthetic skin replacement, dermagraft-tc, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. In: Journal of Burn Care and Rehabilitation. 1997 ; Vol. 18, No. 1. pp. 52-57.
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