A neuroimmunoregulatory-like mechanism responding to stress in the marine bivalve Mytilus edulis

George B. Stefano, Patrick Cadet, Ayotunde Dokun, Berta Scharrer

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Mytilus edulis has been the subject of recent studies to determine whether the relationship between the immune and nervous systems seen in vertebrates also exists in invertebrates. In the present study the effects of experimentally induced "stressful" stimuli on immunoactive hemocytes were studied in this mollusc. This subpopulation of invertebrate blood cells, resembling vertebrate granulocytes, has been previously shown to produce and react to opioid peptides. Their activation, like that of vertebrate immunocytes, expresses itself in distinctive conformational changes preceding cellular mobilization. The cellular response to "stress" observed is the same as that to the administration of exogenous mammalian opioid peptides. This strongly suggests that under the conditions of stressful stimuli, the immune/defense system can be alerted by endogenous neuropeptides. The involvement of opioids in neuroimmunoregulatory phenomena appears to have a long evolutionary history.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalBrain Behavior and Immunity
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1990

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Mytilus edulis
Bivalvia
Vertebrates
Opioid Peptides
Invertebrates
Immune System
Hemocytes
Mollusca
Neuropeptides
Granulocytes
Opioid Analgesics
Nervous System
Blood Cells
History

All Science Journal Classification (ASJC) codes

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

A neuroimmunoregulatory-like mechanism responding to stress in the marine bivalve Mytilus edulis. / Stefano, George B.; Cadet, Patrick; Dokun, Ayotunde; Scharrer, Berta.

In: Brain Behavior and Immunity, Vol. 4, No. 4, 01.01.1990, p. 323-329.

Research output: Contribution to journalArticle

Stefano, George B. ; Cadet, Patrick ; Dokun, Ayotunde ; Scharrer, Berta. / A neuroimmunoregulatory-like mechanism responding to stress in the marine bivalve Mytilus edulis. In: Brain Behavior and Immunity. 1990 ; Vol. 4, No. 4. pp. 323-329.
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