A normative reference database study for Pronosco X-posure System™

Dennis M. Black, Lisa Palermo, Torben Sørensen, Jan T. Jørgensen, Cora Lewis, Frances Tylavsky, Robert Wallace, Emily Harris, Steven R. Cummings

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Cortical width from radiographs has been used for more than 40 yr as a means of estimating bone strength. In the last 5-10 yr, increased availability of computers and the development of automated algorithms for image assessment have led to an increased interest in radiogrammetry. In this study, we examined a new radiogrammetry device, the Pronosco X-posure System™, which estimates bone mineral density (BMD) from forearm/hand radiographs. We obtained hand and forearm radiographs and performed dual X-ray absorptiometry (DXA) at the wrist and hip on 832 women ages 20-79 at four clinical centers across the United States. We then used the X-posure System to estimate BMD (DXR-BMD). The goal of the study was to establish reference ranges for the method and to compare the measurement to DXA measurements of BMD at the wrist and hip. Using statistical models, we estimated that the peak value for DXR-BMD occurred at age 38 (mean = 0.598 g/cm2, standard deviation = 0.034 g/cm2). The correlation between DXR-BMD and DXA was 0.90 at the wrist and 0.61 at the hip. The relationship of DXR-BMD to reported history of fracture was of similar magnitude to that for DXA at the wrist and hip. The strong correlation of DXR-BMD from the X-posure System with DXA at the wrist from the Hologic machine suggests that the X-posure System may be an alternative to DXA at the wrist for the assessment of osteoporosis.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalJournal of Clinical Densitometry
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Bone Density
Photon Absorptiometry
Wrist
Databases
Hip
Forearm
Hand
Statistical Models
Osteoporosis
Reference Values
Bone and Bones
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Black, D. M., Palermo, L., Sørensen, T., Jørgensen, J. T., Lewis, C., Tylavsky, F., ... Cummings, S. R. (2001). A normative reference database study for Pronosco X-posure System™. Journal of Clinical Densitometry, 4(1), 5-12. https://doi.org/10.1385/JCD:4:1:05

A normative reference database study for Pronosco X-posure System™. / Black, Dennis M.; Palermo, Lisa; Sørensen, Torben; Jørgensen, Jan T.; Lewis, Cora; Tylavsky, Frances; Wallace, Robert; Harris, Emily; Cummings, Steven R.

In: Journal of Clinical Densitometry, Vol. 4, No. 1, 01.01.2001, p. 5-12.

Research output: Contribution to journalArticle

Black, DM, Palermo, L, Sørensen, T, Jørgensen, JT, Lewis, C, Tylavsky, F, Wallace, R, Harris, E & Cummings, SR 2001, 'A normative reference database study for Pronosco X-posure System™', Journal of Clinical Densitometry, vol. 4, no. 1, pp. 5-12. https://doi.org/10.1385/JCD:4:1:05
Black, Dennis M. ; Palermo, Lisa ; Sørensen, Torben ; Jørgensen, Jan T. ; Lewis, Cora ; Tylavsky, Frances ; Wallace, Robert ; Harris, Emily ; Cummings, Steven R. / A normative reference database study for Pronosco X-posure System™. In: Journal of Clinical Densitometry. 2001 ; Vol. 4, No. 1. pp. 5-12.
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