A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces

Karrer M. Alghazali, Steven D. Newby, Zeid A. Nima, Rabab N. Hamzah, Fumiya Watanabe, Shawn E. Bourdo, Thomas J. Masi, Stacy Stephenson, David E. Anderson, Madhu Dhar, Alexandru S. Biris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The bioactivity of complex biomaterials used in regenerative medicine depends on their morphological, chemical, and biological profiles. These factors control and enhance the tissue regeneration process. A novel, 2D layered structure for tissue regeneration was developed using amine-functionalized gold nanorods (AuNRs-SH-PEG-NH2). The AuNR nanostructures were PEG-coated and then deposited over a plastic substrate. The AuNR adhered strongly due to its positive charge and the substrates negative charge. In in vitro experiments, the AuNR was shown to behave as a bioactive layer, promoting cell-substrate interaction, as well as cell adhesion and proliferation. Thiolated AuNR with positive amine moieties showed enhanced adherence of cellular proteins. Furthermore, the AuNR system enhanced the neural differentiation of hMSCs.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Nanosystems
Amines
Regeneration
Tissue regeneration
Nanotubes
Polyethylene glycols
Regenerative Medicine
Nanostructures
Biocompatible Materials
Substrates
Cell Adhesion
Cell Communication
Gold
Plastics
Cell adhesion
Cell Proliferation
Cell proliferation
Bioactivity
Nanorods
Biomaterials

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Alghazali, K. M., Newby, S. D., Nima, Z. A., Hamzah, R. N., Watanabe, F., Bourdo, S. E., ... Biris, A. S. (2019). A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. / Alghazali, Karrer M.; Newby, Steven D.; Nima, Zeid A.; Hamzah, Rabab N.; Watanabe, Fumiya; Bourdo, Shawn E.; Masi, Thomas J.; Stephenson, Stacy; Anderson, David E.; Dhar, Madhu; Biris, Alexandru S.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Alghazali, KM, Newby, SD, Nima, ZA, Hamzah, RN, Watanabe, F, Bourdo, SE, Masi, TJ, Stephenson, S, Anderson, DE, Dhar, M & Biris, AS 2019, A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Alghazali KM, Newby SD, Nima ZA, Hamzah RN, Watanabe F, Bourdo SE et al. A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Alghazali, Karrer M. ; Newby, Steven D. ; Nima, Zeid A. ; Hamzah, Rabab N. ; Watanabe, Fumiya ; Bourdo, Shawn E. ; Masi, Thomas J. ; Stephenson, Stacy ; Anderson, David E. ; Dhar, Madhu ; Biris, Alexandru S. / A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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AU - Watanabe, Fumiya

AU - Bourdo, Shawn E.

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