A novel series of urea-based peptidomimetic calpain inhibitors

M. Lee Sanders, Isaac Donkor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.

Original languageEnglish (US)
Pages (from-to)1965-1968
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number7
DOIs
StatePublished - Apr 1 2006

Fingerprint

Peptidomimetics
Aldehydes
Urea
Cathepsin B
Calpain
Nitrogen
Carbon
Derivatives
Peptides
calpain inhibitors

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

A novel series of urea-based peptidomimetic calpain inhibitors. / Sanders, M. Lee; Donkor, Isaac.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 7, 01.04.2006, p. 1965-1968.

Research output: Contribution to journalArticle

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