A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex

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27 Citations (Scopus)

Abstract

Facial angiofibromas are dermatological manifestations of tuberous sclerosis complex, a neurocutaneous disorder characterized by excess cell growth and proliferation. Oral rapamycin has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine precludes its routine use in patients lacking significant internal involvement. The authors formulated a novel rapamycin cream that is easy to compound and apply, does not cause local or systemic side effects, and results in a dramatic improvement of facial angiofibromas.

Original languageEnglish (US)
Pages (from-to)933-936
Number of pages4
JournalJournal of Child Neurology
Volume28
Issue number7
DOIs
StatePublished - Jan 1 2013

Fingerprint

Angiofibroma
Tuberous Sclerosis
Sirolimus
Neurocutaneous Syndromes
Cell Proliferation
Medicine
Therapeutics
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

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