A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion-baboons (Papio spp.)

Giancarlo Mari, Jan Deprest, Mauro Schenone, Scott Jackson, Jacques Samson, Brian Brocato, Danielle Tate, Ryan Sullivan, Garry White, Ramasubbareddy Dhanireddy, Timothy Mandrell, Sonali Gupta, Cezary Skobowjat, Andrzej Slominski, Harris Cohen, Natalia Schlabritz-Loutsevitch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Percutaneous fetoscopic endoluminal reversible tracheal occlusion (FETO) was developed to prevent the pulmonary complications of fetal congenital diaphragmatic herniation. There is an urgent need to establish the closest to human translational model of FETO in order to improve fetal outcomes and to determine new clinical approaches and applications. Material and Methods: Seven non-human primates underwent two subsequent surgeries: the first, the FETO in the experimental group (n = 3) or sham operation in the control animals (S-FETO, n = 4) at 132-142 days of gestation (dGA); the second, the reversal of occlusion or sham operation at 162 ± 5 dGA. Maternal stress axis, complete blood count, and biochemical parameters were evaluated and newborn tracheal radiography was performed. Results: The average pregnancy duration and neonatal weights in the FETO group did not differ from the animals in the S-FETO group. There was no bleeding or premature fetal membrane rupture during the procedures in any of the baboons. The maximal tracheal width was 7.02 ± 0.6 mm in the FETO versus 5.46 ± 0.6 mm in S-FETO group. Discussion: This is the very first report of a successful FETO model in non-human primates. Similarities to human tracheomegaly were for the first time documented in any model studied.

Original languageEnglish (US)
Pages (from-to)92-100
Number of pages9
JournalFetal Diagnosis and Therapy
Volume35
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Papio
Pregnancy
Primates
Premature Rupture Fetal Membranes
Blood Cell Count
Radiography
Mothers
Hemorrhage
Weights and Measures
Lung

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

Cite this

A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion-baboons (Papio spp.). / Mari, Giancarlo; Deprest, Jan; Schenone, Mauro; Jackson, Scott; Samson, Jacques; Brocato, Brian; Tate, Danielle; Sullivan, Ryan; White, Garry; Dhanireddy, Ramasubbareddy; Mandrell, Timothy; Gupta, Sonali; Skobowjat, Cezary; Slominski, Andrzej; Cohen, Harris; Schlabritz-Loutsevitch, Natalia.

In: Fetal Diagnosis and Therapy, Vol. 35, No. 2, 01.01.2014, p. 92-100.

Research output: Contribution to journalArticle

Mari, G, Deprest, J, Schenone, M, Jackson, S, Samson, J, Brocato, B, Tate, D, Sullivan, R, White, G, Dhanireddy, R, Mandrell, T, Gupta, S, Skobowjat, C, Slominski, A, Cohen, H & Schlabritz-Loutsevitch, N 2014, 'A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion-baboons (Papio spp.)', Fetal Diagnosis and Therapy, vol. 35, no. 2, pp. 92-100. https://doi.org/10.1159/000357139
Mari, Giancarlo ; Deprest, Jan ; Schenone, Mauro ; Jackson, Scott ; Samson, Jacques ; Brocato, Brian ; Tate, Danielle ; Sullivan, Ryan ; White, Garry ; Dhanireddy, Ramasubbareddy ; Mandrell, Timothy ; Gupta, Sonali ; Skobowjat, Cezary ; Slominski, Andrzej ; Cohen, Harris ; Schlabritz-Loutsevitch, Natalia. / A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion-baboons (Papio spp.). In: Fetal Diagnosis and Therapy. 2014 ; Vol. 35, No. 2. pp. 92-100.
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