A P450-centric view of plant evolution

David Nelson, Danièle Werck-Reichhart

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Being by far the largest family of enzymes to support plant metabolism, the cytochrome P450s (CYPs) constitute an excellent reporter of metabolism architecture and evolution. The huge superfamily of CYPs found in angiosperms is built on the successful evolution of 11 ancestral genes, with very different fates and progenies. Essential functions in the production of structural components (membrane sterols), light harvesting (carotenoids) or hormone biosynthesis kept some of them under purifying selection, limiting duplication and sub/neofunctionalization. One group (the CYP71 clan) after an early trigger to diversification, has kept growing, producing bursts of gene duplications at an accelerated rate. The CYP71 clan now represents more than half of all CYPs in higher plants. Such bursts of gene duplication are likely to contribute to adaptation to specific niches and to speciation. They also occur, although with lower frequency, in gene families under purifying selection. The CYP complement (CYPomes) of rice and the model grass weed Brachypodium distachyon have been compared to view evolution in a narrower time window. The results show that evolution of new functions in plant metabolism is a very long-term process. Comparative analysis of the plant CYPomes provides information on the successive steps required for the evolution of land plants, and points to several cases of convergent evolution in plant metabolism. It constitutes a very useful tool for spotting essential functions in plant metabolism and to guide investigations on gene function.

Original languageEnglish (US)
Pages (from-to)194-211
Number of pages18
JournalPlant Journal
Volume66
Issue number1
DOIs
StatePublished - Apr 1 2011

Fingerprint

Cytochromes
cytochromes
metabolism
Gene Duplication
gene duplication
Brachypodium
Embryophyta
Brachypodium distachyon
Angiosperms
Metrorrhagia
grass weeds
production functions
convergent evolution
embryophytes
Sterols
Carotenoids
Poaceae
Gene Frequency
sterols
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Plant Science
  • Cell Biology

Cite this

A P450-centric view of plant evolution. / Nelson, David; Werck-Reichhart, Danièle.

In: Plant Journal, Vol. 66, No. 1, 01.04.2011, p. 194-211.

Research output: Contribution to journalArticle

Nelson, David ; Werck-Reichhart, Danièle. / A P450-centric view of plant evolution. In: Plant Journal. 2011 ; Vol. 66, No. 1. pp. 194-211.
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