A phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs

Randal K. Buddington, Victor V. Chizhikov, Igor Y. Iskusnykh, Helen J. Sable, Jeffrey J. Sable, Zade R. Holloway, Tamar Blumenfeld Katzir, Marie van der Merwe, Taisiya Yakimkova, Karyl K. Buddington, Yael Lifshitz, Shoshi Tessler, Ariel Gilbert

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Abstract

The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic acid (DHA), are considered of particular importance, results from clinical trials with preterm infants have been inconclusive because of ethical limitations and confounding variables. A translational large animal model is needed to understand the structural and functional responses to DHA. Neurodevelopment of preterm pigs was evaluated in response to feeding formulas to term-equivalent age supplemented with DHA attached to phosphatidylserine (PS-DHA) or sunflower oil as the placebo. Newborn term pigs were used as a control for normal in utero neurodevelopment. Supplementing formula with PS-DHA increased weight of the brain, and particularly the cerebellum, at term-equivalent age compared with placebo preterm pigs (P’s < 0.10 and 0.05 respectively), with a higher degree of myelination in all regions of the brain examined (all p < 0.06). Brains of pigs provided PS-DHA were similar in weight to newborn term pigs. Event-related brain potentials and performance in a novel object recognition test indicated the PS-DHA supplement accelerated development of sensory pathways and recognition memory compared with placebo preterm pigs. The PS-DHA did not increase weight gain, but was associated with higher survival. The benefits of PS-DHA include improving neurodevelopment and possibly improvement of survival, and justify further studies to define dose-response relations, compare benefits associated with other sources of DHA, and understand the mechanisms underlying the benefits and influences on the development of other tissues and organ systems.

Original languageEnglish (US)
Article number637
JournalNutrients
Volume10
Issue number5
DOIs
StatePublished - May 18 2018

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phosphatidylserines
neurodevelopment
Phosphatidylserines
Swine
swine
Acids
acids
placebos
brain
Placebos
Brain
Premature Infants
neonates
Newborn Infant
myelination
bottle feeding
Weights and Measures
long chain polyunsaturated fatty acids
Confounding Factors (Epidemiology)
cerebellum

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Buddington, R. K., Chizhikov, V. V., Iskusnykh, I. Y., Sable, H. J., Sable, J. J., Holloway, Z. R., ... Gilbert, A. (2018). A phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs. Nutrients, 10(5), [637]. https://doi.org/10.3390/nu10050637

A phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs. / Buddington, Randal K.; Chizhikov, Victor V.; Iskusnykh, Igor Y.; Sable, Helen J.; Sable, Jeffrey J.; Holloway, Zade R.; Katzir, Tamar Blumenfeld; van der Merwe, Marie; Yakimkova, Taisiya; Buddington, Karyl K.; Lifshitz, Yael; Tessler, Shoshi; Gilbert, Ariel.

In: Nutrients, Vol. 10, No. 5, 637, 18.05.2018.

Research output: Contribution to journalArticle

Buddington, RK, Chizhikov, VV, Iskusnykh, IY, Sable, HJ, Sable, JJ, Holloway, ZR, Katzir, TB, van der Merwe, M, Yakimkova, T, Buddington, KK, Lifshitz, Y, Tessler, S & Gilbert, A 2018, 'A phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs', Nutrients, vol. 10, no. 5, 637. https://doi.org/10.3390/nu10050637
Buddington, Randal K. ; Chizhikov, Victor V. ; Iskusnykh, Igor Y. ; Sable, Helen J. ; Sable, Jeffrey J. ; Holloway, Zade R. ; Katzir, Tamar Blumenfeld ; van der Merwe, Marie ; Yakimkova, Taisiya ; Buddington, Karyl K. ; Lifshitz, Yael ; Tessler, Shoshi ; Gilbert, Ariel. / A phosphatidylserine source of docosahexanoic acid improves neurodevelopment and survival of preterm pigs. In: Nutrients. 2018 ; Vol. 10, No. 5.
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