A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease

Sang Lee, Lijing Xu, Yoojin Shin, Lidia Gardner, Anastasia Hartzes, F Dohan, Cedric Raine, Ramin Homayouni, Michael C. Levin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfection of anti-M9 antibodies into neurons resulted in neuronal injury and changes in transcripts related to hnRNP-A1 function. Importantly, RNA levels for the spinal paraplegia genes (SPGs) decreased. Changes in SPG RNA levels were confirmed in neurons purified from MS brains. Also, we show molecular interactions between spastin (the encoded protein of SPG4) and hnRNP-A1. These data suggest a link between autoimmunity, clinical phenotype and neurodegeneration in MS.

Original languageEnglish (US)
Pages (from-to)56-69
Number of pages14
JournalJournal of Neuroimmunology
Volume235
Issue number1-2
DOIs
StatePublished - Jun 1 2011

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Nuclear Proteins
Autoimmunity
Multiple Sclerosis
Paraplegia
RNA
Neurons
Antibodies
Genes
Transfection
Anti-Idiotypic Antibodies
Proteins
Phenotype
Wounds and Injuries
Brain

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease. / Lee, Sang; Xu, Lijing; Shin, Yoojin; Gardner, Lidia; Hartzes, Anastasia; Dohan, F; Raine, Cedric; Homayouni, Ramin; Levin, Michael C.

In: Journal of Neuroimmunology, Vol. 235, No. 1-2, 01.06.2011, p. 56-69.

Research output: Contribution to journalArticle

Lee, Sang ; Xu, Lijing ; Shin, Yoojin ; Gardner, Lidia ; Hartzes, Anastasia ; Dohan, F ; Raine, Cedric ; Homayouni, Ramin ; Levin, Michael C. / A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease. In: Journal of Neuroimmunology. 2011 ; Vol. 235, No. 1-2. pp. 56-69.
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