A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients

Trudye A. Young, Tejesh Patel, Fabian Camacho, Adele Clark, Barry I. Freedman, Mandeep Kaur, Julie Fountain, Lisa L. Williams, Gil Yosipovitch, Alan B. Fleischer

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients. Methods: This was a randomized, double-blind, controlled comparative trial set in a community hemodialysis center. The study population comprised 28 individuals (mean age 53.5) with moderate to severe uremic pruritus who had been receiving hemodialysis for at least 3 months. All participants were recruited from one community hemodialysis center. Topical anti-itch lotion containing 1% pramoxine was applied twice daily to all affected areas of pruritus for 4 weeks. The main outcome measure was a reduction in itch intensity. Secondary outcomes included increases in the investigator's global assessment and improvement in skin hydration. Results: There was a 61% decrease in itch intensity in the treatment group, whereas a 12% reduction in itch intensity was observed in the control group. The rate of decline in itching was also greater in the treatment arm versus the control arm. No significant differences were displayed in other studied disease-related variables. Conclusion: Our study shows that individuals using pramoxine 1% lotion experienced a reduction in pruritus to a greater degree than those using the control lotion. This safe, convenient and effective topical lotion may potentially benefit the large number of patients affected by pruritus associated with end-stage renal disease.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalJournal of Dermatological Treatment
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

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Pruritus
Renal Dialysis
Therapeutics
Chronic Kidney Failure
pramoxine
Research Personnel
Outcome Assessment (Health Care)
Control Groups
Skin
Population

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. / Young, Trudye A.; Patel, Tejesh; Camacho, Fabian; Clark, Adele; Freedman, Barry I.; Kaur, Mandeep; Fountain, Julie; Williams, Lisa L.; Yosipovitch, Gil; Fleischer, Alan B.

In: Journal of Dermatological Treatment, Vol. 20, No. 2, 01.04.2009, p. 76-81.

Research output: Contribution to journalArticle

Young, TA, Patel, T, Camacho, F, Clark, A, Freedman, BI, Kaur, M, Fountain, J, Williams, LL, Yosipovitch, G & Fleischer, AB 2009, 'A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients', Journal of Dermatological Treatment, vol. 20, no. 2, pp. 76-81. https://doi.org/10.1080/09546630802441218
Young, Trudye A. ; Patel, Tejesh ; Camacho, Fabian ; Clark, Adele ; Freedman, Barry I. ; Kaur, Mandeep ; Fountain, Julie ; Williams, Lisa L. ; Yosipovitch, Gil ; Fleischer, Alan B. / A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. In: Journal of Dermatological Treatment. 2009 ; Vol. 20, No. 2. pp. 76-81.
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AU - Clark, Adele

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