A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men

Jay Fowke, Xijing Han, J. F. Alderete, Kelvin A. Moses, Lisa B. Signorello, William J. Blot

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we prospectively investigated this association among AA men. Results: Incident PC cases were individually matched to controls in a nested case-control study within the Southern Community Cohort Study (SCCS). Primary analysis included 296 PC cases and 497 race-matched controls. Levels of Tv antibody response were measured by ELISA in serum collected at baseline. Tv antibody response did not significantly differ between cases and controls overall or within AA participants (253 AA cases). There were no significant associations or trends between levels of Tv response and PC risk or the diagnosis of aggressive PC. Conclusion: We found no evidence of a prospective association between baseline Tv infection and PC risk in AA men. Tv infection in men may have substantial health implications in HIV transmission and reproductive outcomes, but may not impact future PC risk in AA men at high-risk for PC. Further efforts need to define past vs. present Tv infection and to separate pathophysiology from PC detection.

Original languageEnglish (US)
Article number2033
JournalBMC Research Notes
Volume9
Issue number1
DOIs
StatePublished - Apr 18 2016
Externally publishedYes

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Trichomonas vaginalis
African Americans
Prostatic Neoplasms
Trichomonas Infections
Prospective Studies
Antibodies
Antibody Formation
Health
Case-Control Studies
Prostate
Cohort Studies
Enzyme-Linked Immunosorbent Assay
HIV

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men. / Fowke, Jay; Han, Xijing; Alderete, J. F.; Moses, Kelvin A.; Signorello, Lisa B.; Blot, William J.

In: BMC Research Notes, Vol. 9, No. 1, 2033, 18.04.2016.

Research output: Contribution to journalArticle

Fowke, Jay ; Han, Xijing ; Alderete, J. F. ; Moses, Kelvin A. ; Signorello, Lisa B. ; Blot, William J. / A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men. In: BMC Research Notes. 2016 ; Vol. 9, No. 1.
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