A rapidly growing choroidal melanoma

Stephen J. Laquis, John M. Freeman, James Fleming, Matthew Wilson, Barrett G. Haik

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: We describe a rapidly growing choroidal melanoma that failed to respond to consecutive globe-sparing treatments in an individual with ocular melanocytosis. DESIGN: Interventional case report. METHODS: A 53-year-old man with right ocular melanocytosis, decreased vision in the right eye, and right eye pain was referred for suspected choroidal melanoma. The lesion, which measured 2.4 mm × 6.6 mm × 6.0 mm, was treated with transpupillary thermotherapy on two occasions and with iodine-125 (I-125) plaque brachytherapy, both of which failed. Enucleation allowed histologic analysis. RESULTS: At enucleation, the choroidal melanoma in the right eye measured 13.6 mm × 16.5 mm × 16.9 mm, which demonstrated the most rapid growth and doubling time reported in a tumor of this type thus far. Pathologic analysis classified the tumor as a mixed-cell type. CONCLUSION: This case reiterates the association between ocular melanocytosis and choroidal melanoma, provides additional evidence that rapid growth and doubling time may be associated with transpupillary thermotherapy and I-125 plaque failure, and highlights the need to follow those tumors closely.

Original languageEnglish (US)
Pages (from-to)580-581
Number of pages2
JournalAmerican Journal of Ophthalmology
Volume133
Issue number4
DOIs
StatePublished - Apr 9 2002

Fingerprint

Melanoma
Induced Hyperthermia
Eye Pain
Neoplasms
Brachytherapy
Growth
Iodine
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

A rapidly growing choroidal melanoma. / Laquis, Stephen J.; Freeman, John M.; Fleming, James; Wilson, Matthew; Haik, Barrett G.

In: American Journal of Ophthalmology, Vol. 133, No. 4, 09.04.2002, p. 580-581.

Research output: Contribution to journalArticle

Laquis, Stephen J. ; Freeman, John M. ; Fleming, James ; Wilson, Matthew ; Haik, Barrett G. / A rapidly growing choroidal melanoma. In: American Journal of Ophthalmology. 2002 ; Vol. 133, No. 4. pp. 580-581.
@article{7f7dbc23d7c548608a3cd1310a25f356,
title = "A rapidly growing choroidal melanoma",
abstract = "PURPOSE: We describe a rapidly growing choroidal melanoma that failed to respond to consecutive globe-sparing treatments in an individual with ocular melanocytosis. DESIGN: Interventional case report. METHODS: A 53-year-old man with right ocular melanocytosis, decreased vision in the right eye, and right eye pain was referred for suspected choroidal melanoma. The lesion, which measured 2.4 mm × 6.6 mm × 6.0 mm, was treated with transpupillary thermotherapy on two occasions and with iodine-125 (I-125) plaque brachytherapy, both of which failed. Enucleation allowed histologic analysis. RESULTS: At enucleation, the choroidal melanoma in the right eye measured 13.6 mm × 16.5 mm × 16.9 mm, which demonstrated the most rapid growth and doubling time reported in a tumor of this type thus far. Pathologic analysis classified the tumor as a mixed-cell type. CONCLUSION: This case reiterates the association between ocular melanocytosis and choroidal melanoma, provides additional evidence that rapid growth and doubling time may be associated with transpupillary thermotherapy and I-125 plaque failure, and highlights the need to follow those tumors closely.",
author = "Laquis, {Stephen J.} and Freeman, {John M.} and James Fleming and Matthew Wilson and Haik, {Barrett G.}",
year = "2002",
month = "4",
day = "9",
doi = "10.1016/S0002-9394(01)01399-X",
language = "English (US)",
volume = "133",
pages = "580--581",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - A rapidly growing choroidal melanoma

AU - Laquis, Stephen J.

AU - Freeman, John M.

AU - Fleming, James

AU - Wilson, Matthew

AU - Haik, Barrett G.

PY - 2002/4/9

Y1 - 2002/4/9

N2 - PURPOSE: We describe a rapidly growing choroidal melanoma that failed to respond to consecutive globe-sparing treatments in an individual with ocular melanocytosis. DESIGN: Interventional case report. METHODS: A 53-year-old man with right ocular melanocytosis, decreased vision in the right eye, and right eye pain was referred for suspected choroidal melanoma. The lesion, which measured 2.4 mm × 6.6 mm × 6.0 mm, was treated with transpupillary thermotherapy on two occasions and with iodine-125 (I-125) plaque brachytherapy, both of which failed. Enucleation allowed histologic analysis. RESULTS: At enucleation, the choroidal melanoma in the right eye measured 13.6 mm × 16.5 mm × 16.9 mm, which demonstrated the most rapid growth and doubling time reported in a tumor of this type thus far. Pathologic analysis classified the tumor as a mixed-cell type. CONCLUSION: This case reiterates the association between ocular melanocytosis and choroidal melanoma, provides additional evidence that rapid growth and doubling time may be associated with transpupillary thermotherapy and I-125 plaque failure, and highlights the need to follow those tumors closely.

AB - PURPOSE: We describe a rapidly growing choroidal melanoma that failed to respond to consecutive globe-sparing treatments in an individual with ocular melanocytosis. DESIGN: Interventional case report. METHODS: A 53-year-old man with right ocular melanocytosis, decreased vision in the right eye, and right eye pain was referred for suspected choroidal melanoma. The lesion, which measured 2.4 mm × 6.6 mm × 6.0 mm, was treated with transpupillary thermotherapy on two occasions and with iodine-125 (I-125) plaque brachytherapy, both of which failed. Enucleation allowed histologic analysis. RESULTS: At enucleation, the choroidal melanoma in the right eye measured 13.6 mm × 16.5 mm × 16.9 mm, which demonstrated the most rapid growth and doubling time reported in a tumor of this type thus far. Pathologic analysis classified the tumor as a mixed-cell type. CONCLUSION: This case reiterates the association between ocular melanocytosis and choroidal melanoma, provides additional evidence that rapid growth and doubling time may be associated with transpupillary thermotherapy and I-125 plaque failure, and highlights the need to follow those tumors closely.

UR - http://www.scopus.com/inward/record.url?scp=0036207244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036207244&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(01)01399-X

DO - 10.1016/S0002-9394(01)01399-X

M3 - Article

VL - 133

SP - 580

EP - 581

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -