A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis

Lindsay Meyers, Chassidy J. Groover, Joshua Douglas, Sang Lee, David Brand, Michael C. Levin, Lidia A. Gardner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Apolipoprotein A1 (Apo A-I), the most abundant component of high-density lipoprotein (HDL), is an anti-inflammatory molecule, yet its potential role in the pathogenesis of multiple sclerosis (MS) has not been fully investigated. In this study, Western blot analyses of human plasma showed differential Apo A-I expression in healthy controls compared to MS patients. Further, primary progressive MS patients had less plasma Apo A-I than other forms of MS. Using experimental allergic encephalomyelitis (EAE) as a model for MS, Apo A-I deficient mice exhibited worse clinical disease and more neurodegeneration concurrent with increased levels of pro-inflammatory cytokines compared to wild-type animals. These data suggest that Apo A-I plays a role in the pathogenesis of EAE, a model for MS, creating the possibility for agents that increase Apo A-I levels as potential therapies for MS.

Original languageEnglish (US)
Pages (from-to)176-185
Number of pages10
JournalJournal of Neuroimmunology
Volume277
Issue number1-2
DOIs
StatePublished - Dec 15 2014

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Apolipoprotein A-I
Multiple Sclerosis
Autoimmune Experimental Encephalomyelitis
Chronic Progressive Multiple Sclerosis
Wild Animals
HDL Lipoproteins
Anti-Inflammatory Agents
Western Blotting
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis. / Meyers, Lindsay; Groover, Chassidy J.; Douglas, Joshua; Lee, Sang; Brand, David; Levin, Michael C.; Gardner, Lidia A.

In: Journal of Neuroimmunology, Vol. 277, No. 1-2, 15.12.2014, p. 176-185.

Research output: Contribution to journalArticle

Meyers, Lindsay ; Groover, Chassidy J. ; Douglas, Joshua ; Lee, Sang ; Brand, David ; Levin, Michael C. ; Gardner, Lidia A. / A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis. In: Journal of Neuroimmunology. 2014 ; Vol. 277, No. 1-2. pp. 176-185.
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