A role for neutrophils in viral respiratory disease

Jeremy V. Camp, Colleen Jonsson

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Neutrophils are immune cells that are well known to be present during many types of lung diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to acute lung injury. Neutrophils are poorly studied with respect to viral infection, and specifically to respiratory viral disease. Influenza A virus (IAV) infection is the cause of a respiratory disease that poses a significant global public health concern. Influenza disease presents as a relatively mild and self-limiting although highly pathogenic forms exist. Neutrophils increase in the respiratory tract during infection with mild seasonal IAV, moderate and severe epidemic IAV infection, and emerging highly pathogenic avian influenza (HPAI). During severe influenza pneumonia and HPAI infection, the number of neutrophils in the lower respiratory tract is correlated with disease severity. Thus, comparative analyses of the relationship between IAV infection and neutrophils provide insights into the relative contribution of host and viral factors that contribute to disease severity. Herein, we review the contribution of neutrophils to IAV disease pathogenesis and to other respiratory virus infections.

Original languageEnglish (US)
Article number550
JournalFrontiers in Immunology
Volume8
Issue numberMAY
DOIs
StatePublished - May 12 2017
Externally publishedYes

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Virus Diseases
Neutrophils
Influenza A virus
Influenza in Birds
Respiratory Tract Infections
Human Influenza
Acute Lung Injury
Adult Respiratory Distress Syndrome
Respiratory System
Lung Diseases
Pneumonia
Public Health
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

A role for neutrophils in viral respiratory disease. / Camp, Jeremy V.; Jonsson, Colleen.

In: Frontiers in Immunology, Vol. 8, No. MAY, 550, 12.05.2017.

Research output: Contribution to journalReview article

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