A second CYP26 P450 in humans and zebrafish

CYP26B1

Research output: Contribution to journalEditorial

42 Citations (Scopus)

Abstract

A new P450 gene has been found in humans. It has 44% sequence identity to CYP26A1 from human and mouse, which places it in a new subfamily, CYP26B. There is only one human EST from a retinal library (AA012833) that matches the coding region. No homologous ESTs are found in mouse. A zebrafish EST AI721901 shows 68% identity to the human protein. This zebrafish EST is only 41% identical to the zebrafish CYP26A1 protein sequence, so it represents the homolog of the human CYP26B1 sequence. It is not known if this gene product will act on all-trans-retinoic acid like the CYP26A1 protein or if it might hydroxylate the 9-cis- or 13-cis-retinoic acid isoforms not recognized by CYP26A1. The importance of the CYP26A1 P450 in mouse and zebrafish development flags the CYP26B1 gene as a potential developmental gene.

Original languageEnglish (US)
Pages (from-to)345-347
Number of pages3
JournalArchives of Biochemistry and Biophysics
Volume371
Issue number2
DOIs
StatePublished - Nov 15 1999

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Zebrafish
Genes
Expressed Sequence Tags
Zebrafish Proteins
Isotretinoin
Tretinoin
Protein Isoforms
Proteins
Developmental Genes
Retinoic Acid 4-Hydroxylase
Libraries

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

A second CYP26 P450 in humans and zebrafish : CYP26B1. / Nelson, David.

In: Archives of Biochemistry and Biophysics, Vol. 371, No. 2, 15.11.1999, p. 345-347.

Research output: Contribution to journalEditorial

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abstract = "A new P450 gene has been found in humans. It has 44{\%} sequence identity to CYP26A1 from human and mouse, which places it in a new subfamily, CYP26B. There is only one human EST from a retinal library (AA012833) that matches the coding region. No homologous ESTs are found in mouse. A zebrafish EST AI721901 shows 68{\%} identity to the human protein. This zebrafish EST is only 41{\%} identical to the zebrafish CYP26A1 protein sequence, so it represents the homolog of the human CYP26B1 sequence. It is not known if this gene product will act on all-trans-retinoic acid like the CYP26A1 protein or if it might hydroxylate the 9-cis- or 13-cis-retinoic acid isoforms not recognized by CYP26A1. The importance of the CYP26A1 P450 in mouse and zebrafish development flags the CYP26B1 gene as a potential developmental gene.",
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