A sorting signal suppresses IFITM1 restriction of viral entry

Kun Li, Rui Jia, Minghua Li, Yi Min Zheng, Chunhui Miao, Yunfang Yao, Hong Long Ji, Yunqi Geng, Wentao Qiao, Lorraine Albritton, Chen Liang, Shan Lu Liu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.

Original languageEnglish (US)
Pages (from-to)4248-4259
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

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Virus Diseases
Lysosomes
Sorting
Mutation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Li, K., Jia, R., Li, M., Zheng, Y. M., Miao, C., Yao, Y., ... Liu, S. L. (2015). A sorting signal suppresses IFITM1 restriction of viral entry. Journal of Biological Chemistry, 290(7), 4248-4259. https://doi.org/10.1074/jbc.M114.630780

A sorting signal suppresses IFITM1 restriction of viral entry. / Li, Kun; Jia, Rui; Li, Minghua; Zheng, Yi Min; Miao, Chunhui; Yao, Yunfang; Ji, Hong Long; Geng, Yunqi; Qiao, Wentao; Albritton, Lorraine; Liang, Chen; Liu, Shan Lu.

In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4248-4259.

Research output: Contribution to journalArticle

Li, K, Jia, R, Li, M, Zheng, YM, Miao, C, Yao, Y, Ji, HL, Geng, Y, Qiao, W, Albritton, L, Liang, C & Liu, SL 2015, 'A sorting signal suppresses IFITM1 restriction of viral entry', Journal of Biological Chemistry, vol. 290, no. 7, pp. 4248-4259. https://doi.org/10.1074/jbc.M114.630780
Li, Kun ; Jia, Rui ; Li, Minghua ; Zheng, Yi Min ; Miao, Chunhui ; Yao, Yunfang ; Ji, Hong Long ; Geng, Yunqi ; Qiao, Wentao ; Albritton, Lorraine ; Liang, Chen ; Liu, Shan Lu. / A sorting signal suppresses IFITM1 restriction of viral entry. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 7. pp. 4248-4259.
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AU - Geng, Yunqi

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AU - Liu, Shan Lu

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