A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas

Michael Goodman, Roberd M. Bostick, Chiranjeev Dash, Paul Terry, W. Dana Flanders, Jack Mandel

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Despite compelling basic science evidence, the search for causal associations linking specific pro- and anti-oxidants to presumably oxidative stress-related neoplasms, such as colorectal adenoma, has produced inconsistent results. We developed an oxidative balance score (OBS) to characterize the pro-oxidant and anti-oxidant exposures of 2,305 participants in a case-control study of colorectal adenoma that used both endoscopy-confirmed and community controls. Twelve lifestyle medical and dietary factors with known pro- or anti-oxidant properties were considered. Each high anti-oxidant exposure and low pro-oxidant exposure was awarded one or two points depending on the level of exposure, and the points for each OBS component were summed. We observed a significant inverse association between OBS (continuous variable) and colorectal adenoma in the analyses with either community, or endoscopy controls (each p-trend < 0.01). When the OBS was treated as an ordinal variable and a score of ≤3 points was used as the referent category, in the analyses with the endoscopy controls the adjusted odds ratios for scores of 4-6, 7-9, 10-12, 13-15, and 16+, were 0.42, 0.32, 0.22, 0.20, and 0.19, respectively, with all 95% confidence intervals excluding 1.0. The corresponding analysis for community controls showed a similar trend. Our findings are in line with the basic science evidence supporting the role of oxidative stress in colorectal neoplasia.

Original languageEnglish (US)
Pages (from-to)1051-1064
Number of pages14
JournalCancer Causes and Control
Volume19
Issue number10
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

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Oxidants
Adenoma
Reactive Oxygen Species
Endoscopy
Oxidative Stress
Case-Control Studies
Life Style
Neoplasms
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas. / Goodman, Michael; Bostick, Roberd M.; Dash, Chiranjeev; Terry, Paul; Flanders, W. Dana; Mandel, Jack.

In: Cancer Causes and Control, Vol. 19, No. 10, 01.12.2008, p. 1051-1064.

Research output: Contribution to journalArticle

Goodman, Michael ; Bostick, Roberd M. ; Dash, Chiranjeev ; Terry, Paul ; Flanders, W. Dana ; Mandel, Jack. / A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas. In: Cancer Causes and Control. 2008 ; Vol. 19, No. 10. pp. 1051-1064.
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