A Synthetic Peptide Administered with IL-12 Elicits Immunity to Listeria monocytogenes

Mark Miller, Marianne J. Skeen, H. Kirk Ziegler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

IL-12 is a pivotal cytokine signal for the development of Th1-type cellular responses that are required for control of intracellular pathogens. We previously demonstrated that coinjection of IL-12 with heat-killed Listeria monocytogenes, which was not immunogenic when injected alone, elicited intense Ag-specific T cell responses that conferred protection against subsequent challenge with Listeria. Herein we describe the remarkable finding that a nonimmunogenic synthetic peptide corresponding to a dominant MHC class II (H-2k)-restricted listerial determinant, when coinjected i.p. with murine IL-12, elicited potent Ag-specific immune responses that conferred protective immunity against Listeria.

Original languageEnglish (US)
Pages (from-to)3675-3679
Number of pages5
JournalJournal of Immunology
Volume159
Issue number8
StatePublished - Oct 15 1997
Externally publishedYes

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Listeria monocytogenes
Interleukin-12
Immunity
Listeria
Peptides
Hot Temperature
Cytokines
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

A Synthetic Peptide Administered with IL-12 Elicits Immunity to Listeria monocytogenes. / Miller, Mark; Skeen, Marianne J.; Ziegler, H. Kirk.

In: Journal of Immunology, Vol. 159, No. 8, 15.10.1997, p. 3675-3679.

Research output: Contribution to journalArticle

Miller, Mark ; Skeen, Marianne J. ; Ziegler, H. Kirk. / A Synthetic Peptide Administered with IL-12 Elicits Immunity to Listeria monocytogenes. In: Journal of Immunology. 1997 ; Vol. 159, No. 8. pp. 3675-3679.
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