A total synthesis of arenastatin a, an extremely potent cytotoxic depsipeptide, from the okinawan marine sponge dysidea arenaria

Motomasa Kobayashi, Michio Kurosu, Weiqi Wang, Isao Kitagawa

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

An asymmetric synthesis of a cyclic depsipeptide arenastatin A (1), which was isolated from the marine sponge Dysidea arenaria and exhibited extremely potent cytotoxicity with IC505 pg/ml for KB cells, has been accomplished.

Original languageEnglish (US)
Pages (from-to)2394-2396
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number11
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Dysidea
Depsipeptides
KB Cells
Porifera
Cytotoxicity
arenastatin A

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

A total synthesis of arenastatin a, an extremely potent cytotoxic depsipeptide, from the okinawan marine sponge dysidea arenaria. / Kobayashi, Motomasa; Kurosu, Michio; Wang, Weiqi; Kitagawa, Isao.

In: Chemical and Pharmaceutical Bulletin, Vol. 42, No. 11, 01.01.1994, p. 2394-2396.

Research output: Contribution to journalArticle

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