A Transient Receptor Potential Channel Regulates Basal Ganglia Output

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The substantia nigra pars reticulata (SNr) is a key basal ganglia output nucleus critical for movement control. A hallmark of the SNr ?-aminobutyric acid (GABA)-containing projection neurons is their depolarized membrane potential, accompanied by rapid spontaneous spikes. Parkinsonian movement disorders are often associated with abnormalities in SNr GABA neuron firing intensity and/or pattern. A fundamental question is the molecular identity of the ion channels that drive these neurons to a depolarized membrane potential. Recent data show that SNr GABA projection neurons selectively express type 3 canonical transient receptor potential (TRPC3) channels. Such channels are tonically active and mediate an inward, Na*-dependent current, leading to a substantial depolarization and ensuring appropriate firing intensity and pattern in SNr GABA projection neurons. Equally important, TRPC3 channels in SNr GABA neurons are up-regulated by dopamine (DA) released from neighboring nigral DA neuron dendrites. Co-activation of DI and D5 DA receptors leads to a TRPC3 channel mediated inward current and increased firing in SNr GABA neurons, whereas Drlike receptor blockade reduces SNr GABA neuron firing frequency and increases their firing irregularity. TRPC3 channels serve as the effector channels mediating an ultra-short SNc→SNr DA pathway that regulates the firing intensity and pattern of the basal ganglia output neurons.

Original languageEnglish (US)
Pages (from-to)95-118
Number of pages24
JournalReviews in the Neurosciences
Volume21
Issue number2
DOIs
StatePublished - Jan 1 2010

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Transient Receptor Potential Channels
Basal Ganglia
GABAergic Neurons
Neurons
Membrane Potentials
Dopamine
Dopamine D5 Receptors
Aminobutyrates
Pars Reticulata
Dopaminergic Neurons
Movement Disorders
Parkinsonian Disorders
Substantia Nigra
Dendrites
Ion Channels
gamma-Aminobutyric Acid
TRPC3 cation channel

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

A Transient Receptor Potential Channel Regulates Basal Ganglia Output. / Zhou, Fuming.

In: Reviews in the Neurosciences, Vol. 21, No. 2, 01.01.2010, p. 95-118.

Research output: Contribution to journalArticle

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