Aberrant cortical functionality and somatosensory deficits after stroke

Eduardo M. Castillo, Corwin Boake, Joshua I. Breier, Disheng Men, Hector M. Garza, Anthony Passaro, Andrew Papanicolaou

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Damage and/or disconnection of the primary somatosensory cortex (SI) after stroke leads to deficits in touch perception. We used magnetoencephalography to test whether specific patterns of functionality of the somatosensory cortex are associated with different degrees of postacute somatosensory deficit. Nineteen postacute unilateral stroke patients suffering different degrees of somatosensory deficit (six inexistent, six moderate, and seven severe) and eight aged-matched controls underwent high-resolution MRI and whole-head magnetoencephalography recordings of somatosensory-evoked fields and of spontaneous slow oscillatory activity. Amplitude of SI activation after tactile stimulation in the affected and nonaffected hemispheres and delta dipole density (DDD) in the postcentral areas were estimated and compared across the four groups. Severe postacute somatosensory deficit was accompanied, in all cases, with absence of SI responses to stimulation in the affected hand and a significant asymmetry in postcentral DDD toward the affected hemisphere. Patients with moderate sensory loss showed asymmetry in their postcentral DDD (four cases toward the affected hemisphere and two toward the unaffected) but no atypical amplitudes in SI activation. Recordings in stroke patients without somatosensory deficit did not differ from those obtained in controls for SI amplitude or postcentral DDD. In stroke patients, amplitude of SI responses and postcentral DDD show a negative correlation. Lack of activation of SI cortex after stimulation of the affected hand and spontaneous slow oscillatory activity in postcentral areas are neurophysiological correlates of somatosensory deficit in the postacute phase of stroke.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalJournal of Clinical Neurophysiology
Volume25
Issue number3
DOIs
StatePublished - Jun 1 2008

Fingerprint

Stroke
Somatosensory Cortex
Magnetoencephalography
Hand
Touch Perception
Touch
Head

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Castillo, E. M., Boake, C., Breier, J. I., Men, D., Garza, H. M., Passaro, A., & Papanicolaou, A. (2008). Aberrant cortical functionality and somatosensory deficits after stroke. Journal of Clinical Neurophysiology, 25(3), 132-138. https://doi.org/10.1097/WNP.0b013e318176c0d4

Aberrant cortical functionality and somatosensory deficits after stroke. / Castillo, Eduardo M.; Boake, Corwin; Breier, Joshua I.; Men, Disheng; Garza, Hector M.; Passaro, Anthony; Papanicolaou, Andrew.

In: Journal of Clinical Neurophysiology, Vol. 25, No. 3, 01.06.2008, p. 132-138.

Research output: Contribution to journalArticle

Castillo, EM, Boake, C, Breier, JI, Men, D, Garza, HM, Passaro, A & Papanicolaou, A 2008, 'Aberrant cortical functionality and somatosensory deficits after stroke', Journal of Clinical Neurophysiology, vol. 25, no. 3, pp. 132-138. https://doi.org/10.1097/WNP.0b013e318176c0d4
Castillo, Eduardo M. ; Boake, Corwin ; Breier, Joshua I. ; Men, Disheng ; Garza, Hector M. ; Passaro, Anthony ; Papanicolaou, Andrew. / Aberrant cortical functionality and somatosensory deficits after stroke. In: Journal of Clinical Neurophysiology. 2008 ; Vol. 25, No. 3. pp. 132-138.
@article{e2148c889351452396dbe112ba5676a4,
title = "Aberrant cortical functionality and somatosensory deficits after stroke",
abstract = "Damage and/or disconnection of the primary somatosensory cortex (SI) after stroke leads to deficits in touch perception. We used magnetoencephalography to test whether specific patterns of functionality of the somatosensory cortex are associated with different degrees of postacute somatosensory deficit. Nineteen postacute unilateral stroke patients suffering different degrees of somatosensory deficit (six inexistent, six moderate, and seven severe) and eight aged-matched controls underwent high-resolution MRI and whole-head magnetoencephalography recordings of somatosensory-evoked fields and of spontaneous slow oscillatory activity. Amplitude of SI activation after tactile stimulation in the affected and nonaffected hemispheres and delta dipole density (DDD) in the postcentral areas were estimated and compared across the four groups. Severe postacute somatosensory deficit was accompanied, in all cases, with absence of SI responses to stimulation in the affected hand and a significant asymmetry in postcentral DDD toward the affected hemisphere. Patients with moderate sensory loss showed asymmetry in their postcentral DDD (four cases toward the affected hemisphere and two toward the unaffected) but no atypical amplitudes in SI activation. Recordings in stroke patients without somatosensory deficit did not differ from those obtained in controls for SI amplitude or postcentral DDD. In stroke patients, amplitude of SI responses and postcentral DDD show a negative correlation. Lack of activation of SI cortex after stimulation of the affected hand and spontaneous slow oscillatory activity in postcentral areas are neurophysiological correlates of somatosensory deficit in the postacute phase of stroke.",
author = "Castillo, {Eduardo M.} and Corwin Boake and Breier, {Joshua I.} and Disheng Men and Garza, {Hector M.} and Anthony Passaro and Andrew Papanicolaou",
year = "2008",
month = "6",
day = "1",
doi = "10.1097/WNP.0b013e318176c0d4",
language = "English (US)",
volume = "25",
pages = "132--138",
journal = "Journal of Clinical Neurophysiology",
issn = "0736-0258",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Aberrant cortical functionality and somatosensory deficits after stroke

AU - Castillo, Eduardo M.

AU - Boake, Corwin

AU - Breier, Joshua I.

AU - Men, Disheng

AU - Garza, Hector M.

AU - Passaro, Anthony

AU - Papanicolaou, Andrew

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Damage and/or disconnection of the primary somatosensory cortex (SI) after stroke leads to deficits in touch perception. We used magnetoencephalography to test whether specific patterns of functionality of the somatosensory cortex are associated with different degrees of postacute somatosensory deficit. Nineteen postacute unilateral stroke patients suffering different degrees of somatosensory deficit (six inexistent, six moderate, and seven severe) and eight aged-matched controls underwent high-resolution MRI and whole-head magnetoencephalography recordings of somatosensory-evoked fields and of spontaneous slow oscillatory activity. Amplitude of SI activation after tactile stimulation in the affected and nonaffected hemispheres and delta dipole density (DDD) in the postcentral areas were estimated and compared across the four groups. Severe postacute somatosensory deficit was accompanied, in all cases, with absence of SI responses to stimulation in the affected hand and a significant asymmetry in postcentral DDD toward the affected hemisphere. Patients with moderate sensory loss showed asymmetry in their postcentral DDD (four cases toward the affected hemisphere and two toward the unaffected) but no atypical amplitudes in SI activation. Recordings in stroke patients without somatosensory deficit did not differ from those obtained in controls for SI amplitude or postcentral DDD. In stroke patients, amplitude of SI responses and postcentral DDD show a negative correlation. Lack of activation of SI cortex after stimulation of the affected hand and spontaneous slow oscillatory activity in postcentral areas are neurophysiological correlates of somatosensory deficit in the postacute phase of stroke.

AB - Damage and/or disconnection of the primary somatosensory cortex (SI) after stroke leads to deficits in touch perception. We used magnetoencephalography to test whether specific patterns of functionality of the somatosensory cortex are associated with different degrees of postacute somatosensory deficit. Nineteen postacute unilateral stroke patients suffering different degrees of somatosensory deficit (six inexistent, six moderate, and seven severe) and eight aged-matched controls underwent high-resolution MRI and whole-head magnetoencephalography recordings of somatosensory-evoked fields and of spontaneous slow oscillatory activity. Amplitude of SI activation after tactile stimulation in the affected and nonaffected hemispheres and delta dipole density (DDD) in the postcentral areas were estimated and compared across the four groups. Severe postacute somatosensory deficit was accompanied, in all cases, with absence of SI responses to stimulation in the affected hand and a significant asymmetry in postcentral DDD toward the affected hemisphere. Patients with moderate sensory loss showed asymmetry in their postcentral DDD (four cases toward the affected hemisphere and two toward the unaffected) but no atypical amplitudes in SI activation. Recordings in stroke patients without somatosensory deficit did not differ from those obtained in controls for SI amplitude or postcentral DDD. In stroke patients, amplitude of SI responses and postcentral DDD show a negative correlation. Lack of activation of SI cortex after stimulation of the affected hand and spontaneous slow oscillatory activity in postcentral areas are neurophysiological correlates of somatosensory deficit in the postacute phase of stroke.

UR - http://www.scopus.com/inward/record.url?scp=44649113779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44649113779&partnerID=8YFLogxK

U2 - 10.1097/WNP.0b013e318176c0d4

DO - 10.1097/WNP.0b013e318176c0d4

M3 - Article

C2 - 18469729

AN - SCOPUS:44649113779

VL - 25

SP - 132

EP - 138

JO - Journal of Clinical Neurophysiology

JF - Journal of Clinical Neurophysiology

SN - 0736-0258

IS - 3

ER -